Immunological Aspects of Renal Vascular Involvement

  • J. Egido
  • M. Sanchez Crespo
  • L. Hernando
Part of the Ettore Majorana International Science Series book series (EMISS, volume 9)


The majority of cases of human vasculitis are thought to be immunologically mediated. The contribution of experimental models, such as acute serum sickness of rabbits, Arthus reaction (including Arthus nephritis) and virus-induced vasculitis, to the knowledge of the problem is reviewed, emphasizing the mechanisms involved in the deposition of immune complexes and mediator systems of vascular injury.

The following immunological aspects of human vasculitis are especially analyzed:
  • the data supporting participation of immune complexes and of known exogenous and endogenous antigens;

  • the need of an increased vascular permeability to allow the deposition of immune complexes;

  • the mechanisms involved in other vasculitis, such as Henoch Schonlein syndrome and Wegener are granulomatosis.


Systemic Lupus Erythematosus Immune Complex Glomerular Basement Membrane Mixed Cryoglobulinemia Serum Sickness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • J. Egido
    • 1
  • M. Sanchez Crespo
    • 1
  • L. Hernando
    • 1
  1. 1.Servicio de NefrologiaFundacion Jimenéz DiazMadridSpain

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