The Significance of the Detection of Circulating Immune Complexes in Human Glomerulonephritis

  • R. Coppo
  • D. Roccatello
  • C. Rollino
  • G. Martina
  • A. Aprato
  • G. Camussi
  • M. Messina
  • G. Piccoli
Part of the Ettore Majorana International Science Series book series (EMISS, volume 9)

Abstract

Much attention has been devoted to the development of clinically applicable ways of detecting immune complexes (IC) in the circulation. Through a reliable IC assay it is hoped to obtain information about the pathogenesis, diagnosis and prognosis of human glomerulonephritis. The authors present a critical re-evaluation of their own data, with a follow-up of 1–42 months. The authors’ experience refers to 428 sera from 207 patients affected by idiopathic or secondary glomerulonephritis. In the last 4 years 3 tests for the detection of circulating IC were employed: solid phase C1q test, PEG precipitation test and PMN immunohistological technique. The limits and specificity of each test and the diagnostic significance of the data obtained in nephropathic patients are discussed.

Keywords

Arthritis Hepatitis Mercury Sedimentation Prednisone 

List of Abbreviations

IC

immune complexes

AHG

aggregated human γ-globulins

PEG

polyethylene glycol

EM

electron microscopy

IF

immunofluorescence

GN

glomerulonephritis

N.S.

non significant

PMN

polymorphonuclear neutrophil

SLE

systemic lupus erythematosus

SP — Clq

solid phase — Clq

O.D. 280 nm

optical density (asorbance) at 280 nm

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • R. Coppo
    • 1
    • 2
  • D. Roccatello
    • 1
    • 2
  • C. Rollino
    • 1
    • 2
  • G. Martina
    • 1
    • 2
  • A. Aprato
    • 1
    • 2
  • G. Camussi
    • 1
    • 2
  • M. Messina
    • 1
    • 2
  • G. Piccoli
    • 1
    • 2
  1. 1.Cattedra di Nefrologia Medica dell’UniversitaTurinItaly
  2. 2.Divisioni di Nefrologia e DialisiOspedale Maggiore di San Giovanni BattistaTurinItaly

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