Long-Term Treatment with Thiazide in the Prevention of Calcium Nephrolithiasis
During the last 4 years, we have examined 292 patients with recurrent calcium nephrolithiasis. During 1845 years of lithiasis, they had formed 2340 stones, with a mean interval between two stone events of about 9 months. Hypercalciuria was observed in 56%, and hyperuricosuria in 22% of the patients.
A reliable follow-up after thiazide administration (hydrochlorothiazide 50 mg + amiloride 5 mg per day) was obtained in 161 patients, treated for 4–48 months (mean 18 months). During the treatment, 15 new stones were formed, in contrast with the 305 predicted. In our experience, thiazide (associated with allopurinol in patients with hyperuricosuria) is very effective in preventing the recurrences of calcium nephrolithiasis.
KeywordsCalcium Excretion Urinary Calcium Excretion Idiopathic Hypercalciuria Serum Uric Acid Concentration Urinary Magnesium
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