The Abnormalities of the Complement System in Human Glomerulonephritis

  • F. C. Berthoux
  • B. Laurent
  • C. Genin
  • J. C. Sabatier
Part of the Ettore Majorana International Science Series book series (EMISS, volume 9)


The implication of the complement system in the pathogenesis of human glomerulonephritis (GN) has been suspected since the work of Zinsser and Johnson in 1911 (31) and of Gunn in 1914 (14).


Complement System Circulate Immune Complex Complement Deficiency Subacute Bacterial Endocarditis Alternate Pathway Activator 
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List of Abbreviations


acute glomerulonephritis


total complement hemolytic activity


circulating immune complexes




immune complexes




membrano-proliferative glomerulonephritis

NF or NeF

nephritic factor




systemic lypus erithematosus


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  1. 1.
    Alper, C.A. and Rosen, F.S.: Genetic aspects of the complement system. In “Advances in Immunology” 14: 251, (1971).CrossRefGoogle Scholar
  2. 2.
    Berthoux, F.C., Carpenter, C.B., Traeger, J. and Merril, J.P.: The C3 Nephritic Factor (CSNeF) and the heat labile complement inactivator (HLCI) in chronic hypocomplementemic mesagio- proliferative glomerulonephritis. In “Advances in Nephrology”. Edited by J. Hamburger, J. Crosnier and M.J. Maxwell. 4: 91, (1974).Google Scholar
  3. 3.
    Berthoux, F.C., Ducret, F., Touraine, J.L. and Traeger, J.: Increased recurrence of mesangioproliferative glomerulonephritis (MPGN) on kidney grafts. Transpl. Proc. 7: 699, (1975).Google Scholar
  4. 4.
    Berthoux, F.C., Ducret, F., Colon, S., Blanc-Brunat, N., Zech, P.Y. and Traeger, J.: Renal transplantation in mesangioproliferative glomerulonephritis (MPGN): Relationship between the high frequency of recurrent glomerulonephritis and hypocomplementemia. Kidney Int. 7: 323, (1975).Google Scholar
  5. 5.
    Berthoux, F.C., Carpenter, C.B., Freyria, A.M., Traeger, J, and Merrill, J.P.: Human glomerulonephritis and the C3 Nephritic Factor (C3NeF). Clinical Nephrology 5: 93, (1976).Google Scholar
  6. 6.
    Berthoux, F.C., Olivier, J.A., Freyria, A.M., Colon, S., Zech, P.Y. and Traeger, J.: Etude des systèmes complément et proper- dine dans Ie lupus érythémateux disséminé (LED) avec atteinte rénale: valeur diagnostique et pronostique. Lyon Médical 235: 31, (1976).Google Scholar
  7. 7.
    Berthoux, F.C.: Intérêt pratique de 1’étude des systèmes com- plément et properdine en pathologie rénale. Lyon Médical 236: 497, (1976).Google Scholar
  8. 8.
    Berthoux, F.C. and Freyria, A.M.: Dosage spécifique des activa- teurs de la voie alternative du système complément dans les glomérulonéphrites humaines: 125 cas. Néphrologie, 1980 (In press).Google Scholar
  9. 9.
    Berthoux, F.C., Laurent, B., Genin, C. and Sabatier, J.C.: Detection of circulating immune complexes (CIC) in human glomerulonephritis (GN, 128 cases). 4th International Congress of Immunology. July 1980, Paris (In press).Google Scholar
  10. 10.
    Curtis, J.J., Wyatt, R.J., Bhatena, D., Lucas, B.A., Holland, N.H., Luke, R.G. and Forristal, J.: Renal transplantation for patients with type I and type II membranoproliferative glomerulonephritis. Am. J. Med, 66: 216, (1979).CrossRefGoogle Scholar
  11. 11.
    Daha, M.R., Austen, K.F. and Fearon, D.T.: Heterogeneity, polypeptide chain composition and antigenic reactivity of C3 Nephritic Factor. J. Immunol. 120: 1389, (1978).Google Scholar
  12. 12.
    Freyria, A.M., Vincent, C., Berthoux, F.C., Revillard, J.P. and Traeger, J.: Clq binding immune complexes and C3 nephritic factor (C3NeF) in hypocomplementemic glomerulonaphritis. In “Protides of the Biological Fluids” (H. Peeters ed.) 26: 301, (1979).Google Scholar
  13. 13.
    Gewürz, H., Pickering, R.J., Mergenhagen, S.G. and Good, R.A.: The complement profile in acute glomerulonephritis, systemic lupus erythematosus and hypocomplementemic chronic glomerulonephritis. Int. Arch. Allergy 34: 556, (1968).CrossRefGoogle Scholar
  14. 14.
    Gunn, W.C.: The variation in the amount of complement in the blood in some acute infectious diseases and its relation to the clinical features. J. Path. Bact. 19: 155, (1914).CrossRefGoogle Scholar
  15. 15.
    Hunsicker, L.G., Ruddy, S., Carpenter, C.B., Schur, P.H., Merrill, J.P., Müller-Eberhard, H.J. and Austen, K.F.: Metabolism of the classical and alternate (properdin) pathways for complement activation. New Engl. J. Med. 287: 837, (1972).CrossRefGoogle Scholar
  16. 16.
    Kazatchkine, M., Nydegger, U. and Fearon, D.T.: La voie alterne du complément. Nouv. Presse Med. 8: 2187, (1979).Google Scholar
  17. 17.
    Lange, K., Wasserman, E. and Slobody, G: The significance of serum complement levels for the diagnosis and prognosis of acute and subacute glomerulonephritis and lupus erythematosus disseminatus. Ann. Int. Med. 53: 636, (1960).Google Scholar
  18. 18.
    Leibowitch, J., Halbwachs, L., Wattel, S., Gaillard, M.H. and Droz, D.: Recurrence of dense deposits in transplanted kidney: II Serum complement and nephritic factor profiles. Kidney Int. 15: 396, (1979).CrossRefGoogle Scholar
  19. 19.
    Leibowitch J. and Lesavre, P.: Progrès dans la connaissance du complément II. Les facteurs néphritiques. Nouv. Presse Méd. 8: 2447, (1979).Google Scholar
  20. 20.
    Lesavre, P. and Leibowitch, J.: Progrès dans la connaissance du complément: I — Structure, activation et controle du systéme complémentaire. Nouv. Presse Méd. 8: 2385, (1979).Google Scholar
  21. 21.
    Lewis, E.J., Carpenter, C.B. and Schur, P.H.: Serum complement component levels in human glomerulonephritis. Ann. Int. Med. 1971: 75: 555, (1971).Google Scholar
  22. 22.
    Roncato, M., Vial, M.C., Maillet, F. and Peltier, A.: Hypo- complementémies de consommation: intérêt comparé des dosages hémolytiques et protéiques des composants de la voie classique du complément. Nouv. Presse Méd. 8: 1657, (1979).Google Scholar
  23. 23.
    Ruddy, S., Gigli, I. and Austen, K.F.: The complement system of man. New Engl. J. Med. 287: 489, (1972).Google Scholar
  24. 24.
    Schur, P.H.: Lupus érithémateux. In “Actualités Néphrologiques de l’Hopital Necker”, pp. 58–70, E.M. Flammarion Ed., (1976).Google Scholar
  25. 25.
    Sissons, J.G.P., West, R.J., Fallows, D., Williams, D.G., Boucher, B.J., Amos, N., Peters, D.K.: The complement abnormalities of lypodystrophy. New Engl. J. Med. 294: 461, (1976).CrossRefGoogle Scholar
  26. 26.
    Sjöholm, A.G.: Complement components and complement activation in Acute Post-Streptococcal Glomerulonephritis. Intern. Arch. Allergy Appl. Immunol. 58: 274, (1979).CrossRefGoogle Scholar
  27. 27.
    Spitzer, R.E., Vallota, E.M., Forristal, J., Sudora, E., S itzel, A., Davis, N.C. and West, C.D.: Serum C3 lytic system in patients with glomerulonephritis. Science 164: 436, (1969).ADSCrossRefGoogle Scholar
  28. 28.
    Whaley, K., Ward, D. and Ruddy, S.: Modulation of the properdin amplification loop in membranoproliferative and other forms of glomerulonephritis. Clin. Exp. Immunol. 35: 101, (1979).Google Scholar
  29. 29.
    Whaley, K., Schur, P.H. and Ruddy, S.: Relative importance of C3b inactivator and IH globulin in the modulation of the properdin amplification loop in systemic lupus erythematosus. Clin. Exp. Immunol. 36: 408, (1979).Google Scholar
  30. 30.
    Wyatt, R.J., Mc Adams, A.J., Forristal, J., Snyder, J. and West, C.D.: Glomerular deposition of complement, control proteins in acute and chronic glomerulonephritis. Kidney Int. 16: 505, (1979).CrossRefGoogle Scholar
  31. 31.
    Zinsser, H. and Johnson, W.C.: On heat sensitive anticomplementary bodies in human blood serum. J. Exp. Med. 13: 31, (1911).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • F. C. Berthoux
    • 1
  • B. Laurent
    • 1
  • C. Genin
    • 1
  • J. C. Sabatier
    • 1
  1. 1.Groupe de Recherches sur le Complément et les Glomérulonéphrites Humaines Service de NephrologieUER de Médecine et Hôpital de BellevueSaint-EtienneFrance

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