Uric Acid Nephrolithiasis — Prevalence, Pathogenesis and Results of Conservative Treatment
In Italy about 25% of all renal calculi are composed of uric acid and/or urates. This percentage includes also the cases with mixed stones (uric acid + calcium oxalate and/or apatite). In our series uric acid nephrolithiasis was idiopathic in 60% of the cases, while in 40% it was associated with abnormal purine metabolism. Our extended observation confirms our previous therapeutic experience and is similar to that of other investigators in this field. Simple dietary measures, adequate hydration and control of urine hyperacidity were considered satisfactory therapy. This was proved by the decrease in frequency of new stone formation, and by complete or partial stone dissolution, thereby decreasing the number of surgical procedures. Allopurinol is the drug of choice in recurrent uric acid lithiasis associated with hyperuricosuric states.
KeywordsUric Acid Calcium Oxalate Polycythemia Vera Glycogen Storage Disease Uric Acid Stone
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