Renal Stone Inhibitors

  • F. Corrado
  • M. Fini
  • A. Ligabue
Part of the Ettore Majorana International Science Series book series (EMISS, volume 9)


The size and the degree of aggregation of crystals, dependent on salt saturation and crystal inhibitor concentration, seem to be the main differences between stone-formers and healthy subjects.

Citrate, pyrophosphate and magnesium inhibit calcium-oxalate and calcium-phosphate crystal formation and growth, while glycosaminoglycans and diphosphonates are crystal aggregation inhibitors.

The role of uric acid in the pathogenesis of calcium-oxalate lithiasis is reviewed, as well as the methods employed for identification and measurement of urinary inhibitors. We present a simple new method to evaluate the inhibitory capacity of urine with regard to calcium-oxalate crystal growth.


Calcium Phosphate Stone Formation Calcium Oxalate Amorphous Calcium Phosphate Urinary Calculus 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • F. Corrado
    • 1
  • M. Fini
    • 1
  • A. Ligabue
    • 1
  1. 1.Department of UrologyM. Malpighi HospitalBolognaItaly

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