Advertisement

The Reactions of Renal Excretory Function in Normotensive and Essentially Hypertensive Men in Response to Oral Administration of Almitrine Bismesylate

  • M. Wiersbitzky
  • R. Schuster
  • F. Balke
  • D. Gaszow
  • B. Wedler
  • A. Honig

Abstract

It is well established now that arterial chemoreceptor structure and mode of action are altered in primary systemic hypertension (Alho et al., 1984; Barer et al., 1987; Habeck, 1986; Habeck et al., 1987; Heath et al., 1982; Lange, 1962). In both humans and animals suffering from this disease abnormal autonomic nervous and cardiorespiratory reactions were found when the arterial chemoreceptors were stimulated (Barer et al., 1987; Huckstorf et al., 1987; Przybylski et al., 1982; Quies et al., 1983; Sofola and Egbe, 1981; Somers et al., 1988; Tafil-Klawe et al., 1985; Tiedt, 1987; Trzebski et al., 1982; Vlachogianni et al., 1989).

Keywords

Carotid Body Hypertensive Subject Breathing Rate Systemic Arterial Blood Pressure Arterial Chemoreceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alho, H., Partanen, M., Koistinaho, J., Vaalasti, A., and Hervonen, A., 1984, Histochemically demonstrabel catecholamines in sympathetic ganglia and carotid body of spontaneously hypertensive and normotensive rats, Histochemistry, 80:457.CrossRefGoogle Scholar
  2. Bardsley, P. A., and Suggett, A. J., 1987, The carotid body and natriuresis: Effect of almitrine bismesylate, Biomed. Biochim. Acta, 46:1017.Google Scholar
  3. Barer, G., Bee, D., Fallot, D., and Jones, S., 1987, Size of the carotid body and ventilatory responses to hypoxia in genetically hypertensive rats, Biomed. Biochim. Acta, 46:919.Google Scholar
  4. De Backer, W., Vermeire, P., Bogaert, E., Janssens, E., and Van Maele, R., 1985, Almitrine has no effect on gas exchange after bilateral carotid body resection in severe chronic airway obstruction. Bull. Eur. Physiophath. Resp., 21:427.Google Scholar
  5. Habeck, J.-O., 1986, Morphological findings at the carotid bodies of humans suffering from different types of systemic hypertension or severe lung diseases, Anat. Anz., 162:17.Google Scholar
  6. Habeck, J.-O., Kuckstorf, C., and Moritz, V., 1987, A comparison of carotid body volumes in normotensive Wistar rats (NWR), Wistar Kyoto rats (WKY), and spontaneously hypertensive rats (SHR), Biomed. Biochim. Acta, 46:907.Google Scholar
  7. Heath, D., Smith, P., and Jago, R., 1982, Hyperplasia of the carotid body, J. Pathol., 138:115.CrossRefGoogle Scholar
  8. Honig, A., 1989, The peripheral arterial chemoreceptors and the reflex control of sodium and water homeostasis. Am. J. Physiol. - submitted for publication.Google Scholar
  9. Honig, A., Wedler, B., Zingler, C., Ledderhos, C., and Schmidt, M., 1985, Kidney function during arterial chemoreceptor stimulation. - III. Long-lasting inhibition of renal tubular sodium reabsorption due to pharmacological stimulation of the peripheral arterial chemoreceptors with almitrine bismesylate, Biomed. Biochim. Acta, 44:1659.Google Scholar
  10. Kuckstorf, C., Behm, R., Habeck, J.-O., Rückborn, K., and Franz, U., 1987, Blood pressure, heart rate, and arterial blood gas reactions to acute hypoxia in carotid body denervated spontaneously hypertensive rats, Biomed. Biochim. Acta, 46:925.Google Scholar
  11. Lange, F. 1962, Vergrößerung des Glomus caroticum bei allen Formen der Hypertonie, Dtsch. Med. Wschr., 87:13.CrossRefGoogle Scholar
  12. Laubie, M., and Schmitt, H., 1980, Long-lasting hyperventilation induced by almitrine: Evidence for a specific effect on carotid and thoracic chemoreceptors, Eur. J. Pharmacol., 61:125.CrossRefGoogle Scholar
  13. Ledderhos, C., Quies, W., Schuster, R., and Peters, R., 1987, Renal hemodynamics and excretory function of healthy young men during stimulation of their peripheral arterial chemoreceptors by almitrine bismesylate, Biomed. Biochim. Acta, 46:1035.Google Scholar
  14. Przybylski, J., Trzebski, A., Czyzewski, T., and Jodkowski, J., 1982, Responses to hyperoxia, hypoxia, hypercapnia, and almitrine in spontaneously hypertensive rats. Bull. Eur. Physiopathol. Respir., 18:145.Google Scholar
  15. Quies, W., Claus, T., and Honig, A., 1983, Die Hyperventilation der Hypertoniker. - Eine Pilotstudie zum Verhalten der Reflexe der arteriellen Chemoreceptoren bei hypertensiven Erkrankungen, Dtsch. Gesundh.- Wesen, 38:612.Google Scholar
  16. Schmidt, M., Ledderhos, C., Kretschmann, B., Schuster, R., and Honig, A., 1987, Influence of infusion of desoxycorticosteroneacetate (DOCA) on the responses of kidney function elicited by stimulation of the peripheral arterial chemoreceptors with almitrine bismesylate in anaesthetized rats, Biomed. Biochim. Acta, 46:1027.Google Scholar
  17. Sofola, O. A., and Egbe, P. E., 1981, Carotid chemoreceptor reflexes in normotensive and spontaneously hypertensive rats. Gen. Pharmacol., 12:459.CrossRefGoogle Scholar
  18. Somers, V. K., Mark, A. L., and Abboud, F. M., 1988, Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension, 11:608.Google Scholar
  19. Stanley, N. N., Galloway, J. M., Flint, K. C., and Campbell, D. B., 1983, Increased respiratory chemosensitivity induced by oral almitrine in healthy man, Brit. J. Pis. Chest, 77:136.CrossRefGoogle Scholar
  20. Tafil-Klawe, M., Trzebski, A., Klawe, J., and Palko, T., 1985, Augmented chemoreceptor reflex tonic drive in early human hypertension and in normotensive subjects with family background of hypertension. Acta Physiol. Pol., 36:51.Google Scholar
  21. Tiedt, N., 1987, Orthostatic cardiovascular regulation during hypoxia and hyperoxia in patients with juvenile hypertension. Biomed. Biochim. Acta, 46:933.Google Scholar
  22. Trzebski, A., Tafil, M., Zoltowski, M., and Przybylski, J., 1982, Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension, Cardiovasc. Res., 16:163.CrossRefGoogle Scholar
  23. Vlachogianni, E. D., Sandberg, B., Gislason, T., and Stalenheim, G., 1989, High ventilatory response to hypoxia in hypertensive patients with sleep apnea, Uppsala J. Med. Sci., 94:89.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • M. Wiersbitzky
    • 1
  • R. Schuster
    • 1
  • F. Balke
    • 1
  • D. Gaszow
    • 1
  • B. Wedler
    • 1
  • A. Honig
    • 1
  1. 1.Clinic of Internal Medicine and Institute of PhysiologyErnst-Moritz-Arndt-UniversityGreifswaldGDR

Personalised recommendations