Involvement of Na+:H+ and Na+:Ca++ Antiporters in the Chemotransduction of Acidic Stimuli
It is generally accepted that the primary chemoreceptor elements in the mammalian carotid body are the type-I cells, which respond to low pO2, high pCO2, or low pH by secreting neurotransmitters which activate the sensory nerve endings synaptically connected with them1. One of the putative neurotransmitters synthesized and secreted by type-I cells in greater amounts is dopamine, and its release by isolated carotid bodies in vitro is an appropriate indicator of the activation of chemoreceptor cells by the different stimuli2.
KeywordsFree Medium Dopamine Release Carotid Body Secretory Response Sodium Pump
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