Advertisement

Medullary Respiratory Neurons with Projections to the Ventral Surface of the Medulla in the Guinea Pig

  • M. Glogowska
  • P.-E. Paulev
  • M. Pokorski

Abstract

It is widely accepted that the central respiratory chemoreceptors are located near the surface of the ventrolateral medulla (VLM) in a position that renders them readily influenced by CO2−H+ changes in both arterial blood and cerebrospinal fluid (Millhorn and Eldridge, 1986); the latter being facilitated by fenestrated medullary surface of the area in question (Dermietzel, 1975). Despite decades of research, neither have the chemo- receptor structure and pathways involved been identified nor were they attainable to record their afferent activity. Location of the central chemoreceptors is based on indirect evidence showing that electrocoagulation, cooling, or stimulation of circumscribed zones on the VLM alter the ventilatory response to certain stimuli (Loeschcke, 1982).

Keywords

Ventilatory Response Area Postrema Ventrolateral Medulla Dorsal Motor Nucleus Nucleus Ambiguus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahmad, H. R., and Loeschcke, H. H., 1982, Transient and steady state responses of pulmonary ventilation to the medullary extracellular pH after approximately rectangular changes in alveolar PCO2, Pflügers Arch., 395:285.CrossRefGoogle Scholar
  2. Comroe, J. H., 1943, The effects of direct chemical and electrical stimulation of the respiratory center in the cat. Am. J. Physiol., 139: 490.Google Scholar
  3. Dermietzel, R., 1975, Central chemosensitivity, morphological studiesin: “Acid Base Homeostasis of the Brain Extracellular Fluid and the Respiratory Control System,” H. H. Loeschcke, ed., Georg Thieme Verlag, Stuttgart.Google Scholar
  4. Loeschcke, H. H., 1982, Central chemosensitivity and the reaction theoryJ. Physiol. (Lond.), 332:1.Google Scholar
  5. Mesulam, M. M., 1978, Tetramethyl benzidine for horseradish peroxidaseneurohistochemistry: A non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferentsJ. Histochem. Cytochem., 26:106.CrossRefGoogle Scholar
  6. Miles, R., 1983, Does low pH stimulate central chemoreceptors located near the ventral medullary surface?. Brain Res., 271:349.CrossRefGoogle Scholar
  7. Millhorn, D. E., and Eldridge, F. L., 1986, Role of ventrolateral medulla in regulation of respiratory and cardiovascular systemJ. Appl. Physiol., 61:1249.Google Scholar
  8. Mitchell, R. A., and Herbert, D. A., 1974, Effect of carbon dioxide on the membrane potential of medullary respiratory neurons. Brain Res., 75:345.CrossRefGoogle Scholar
  9. Nye, P. C. G., Hanson, M. A., and Torrance, R. W., 1983, The effect on breathing of abruptly reducing the discharge of central chemoreceptorsResp. Physiol., 51:109.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • M. Glogowska
    • 1
  • P.-E. Paulev
    • 2
  • M. Pokorski
    • 1
  1. 1.Dept. of NeurophysiologyPolish Academy of Sciences Medical Research CenterWarsawPoland
  2. 2.University of Copenhagen Medical Physiology Sports/CyberneticsCopenhagenDenmark

Personalised recommendations