Medullary Respiratory Neurons with Projections to the Ventral Surface of the Medulla in the Guinea Pig
It is widely accepted that the central respiratory chemoreceptors are located near the surface of the ventrolateral medulla (VLM) in a position that renders them readily influenced by CO2−H+ changes in both arterial blood and cerebrospinal fluid (Millhorn and Eldridge, 1986); the latter being facilitated by fenestrated medullary surface of the area in question (Dermietzel, 1975). Despite decades of research, neither have the chemo- receptor structure and pathways involved been identified nor were they attainable to record their afferent activity. Location of the central chemoreceptors is based on indirect evidence showing that electrocoagulation, cooling, or stimulation of circumscribed zones on the VLM alter the ventilatory response to certain stimuli (Loeschcke, 1982).
KeywordsVentilatory Response Area Postrema Ventrolateral Medulla Dorsal Motor Nucleus Nucleus Ambiguus
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