Action of Almitrine on the Laryngeal Passage in Cats

  • M. Szereda-Przestaszewska
  • J. Jakus
  • A. Stránsky


There have been a number of animal and human studies regarding the effects of almitrine bismesylate on ventilatory parameters. The size of respiratory changes depends on the preserved integrity of the carotid sinus and vagal nerves (Laubie and Diot, 1972; Laubie and Schmitt, 1980; Dhillon and Barer, 1982; De Backer et al., 1985), which befits with the pattern of the hypoxic response. The latter is known to elicit the expiratory vocal cord abduction, i.e. the decline in the resistance to flow posed by the larynx. Furthermore, the ammeliorating effect of almitrine bismesylate in patients with OSAS (Krieger et al., 1982) suggests that the upper airway airflow resistance might lower. No studies are yet available devoted to the evaluation of this problem. We have investigated the laryngeal response to almitrine bismesylate in cats, trying to assess the contribution of the vagal and sensory laryngeal inputs.


Vocal Cord Recurrent Laryngeal Nerve Carotid Body Superior Laryngeal Nerve Sodium Cyanide 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bartlett, D., Jr., 1979, Effects of hypercapnia and hypoxia on laryngeal resistance to airflowRespir. Physiol., 37:293.CrossRefGoogle Scholar
  2. Bartlett, D., Jr., 1980, Effects of vagal afferents on laryngeal responses to hypercapnia and hypoxiaRespir. Physiol., 42:189.CrossRefGoogle Scholar
  3. Bartlett, D., Jr., and Knuth, S. L., 1984, Human vocal cord movements during voluntary hyperventilationRespir. Physiol., 58:289.CrossRefGoogle Scholar
  4. De Backer, W., Vermeire, P., Bogaert, E., Janssens, E., and Van Maele, R., 1985, Almitrine has no effect on gas exchange after bilateral carotid body resection in severe chronic airflow obstruction. Bull. Eur. Physiopathol. Resp., 21:427.Google Scholar
  5. Dhillon, D. P., and Barer, G. R., 1982, Respiratory stimulation by almitrine during acute or chronic hypoxia/hypercapnia in rats. Bull. Eur. Physiopathol. Resp., 18:751.Google Scholar
  6. Dixon, M., Szereda-Przestaszewska, M., Widdicombe, J. G., and Wise, J. C. M., 1974, Studies on laryngeal calibre during stimulation of peripheral and central chemoreceptors, pneumothorax and increased respiratory loadsJ. Physiol. (Lond.), 239:347.Google Scholar
  7. Gregg, R. L., 1956, Experimental laryngeal paralysisAnn. Otol. Rhinol. Laryngol., 65:634.Google Scholar
  8. Horiuchi, M., and Sasaki, C. T., 1978, Circothyroid muscle in respirationAnn. Otol. Rhinol. Laryngol., 87:1.Google Scholar
  9. Krieger, J., Mangin, P., and Kurtz, D., 1982, Effects of a ventilator stimulant almitrine bismesylate, in the sleep apnea syndromeCurr. Ther. Res., 32:697.Google Scholar
  10. Laubie, M., and Diot, F., 1972, A pharmacological study of the respiratory stimulant action of S. 2620. The role of the carotid and aortic chemoreceptorsJ. Pharmacol. (Paris), 3:363.Google Scholar
  11. Laubie, M., and Schmitt, H., 1980, Long-lasting hyperventilation induced by almitrine: evidence for the specific effect on carotid and thoracic chemoreceptorsEur. J. Pharmacol., 61:125.CrossRefGoogle Scholar
  12. Mc Caffrey, V., and Kern, E. B., 1980, Laryngeal reulation of airway resistance. I. Chemoreceptor reflexesAnn. Otol. Rhinol. Laryngol., 89:209.Google Scholar
  13. Oliven, A., Odeh, A., and Gavriely, N., 1989, Effect of salicylate on upper airway dilating muscles in anesthetized dogs. Am. Rev. Respir. Dis., 139:170.CrossRefGoogle Scholar
  14. Sherrey, J. H., and Megirian, D., 1974, Spontaneous and reflexly evoked laryngeal abductor and adductor muscle activity of catExp. Neurol., 43:487.CrossRefGoogle Scholar
  15. Strohl, K. P. Gottfried, S. B., Van de Graaf, W., Wood, R. E., and Fouke, J. M., 1986, Effects of sodium cyanide and nicotine on upper airway resistance in anesthetized dogsRespir. Physiol., 63:161.CrossRefGoogle Scholar
  16. Szereda-Przestaszewska, M., 1986, Respiratory effects of chronic intrathoracic vagotomy in rabbits. Respiration, 49:122.CrossRefGoogle Scholar
  17. Yoshida, Y., Tanaka, Y., Mitsumasu, T., Hirano, M., and Kanasaki, T., 1986, Peripheral course and intramucosal distribution of the larnygeal sensory nerve fibres of cats. Brain Res. Bull., 17:95.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • M. Szereda-Przestaszewska
    • 1
  • J. Jakus
    • 2
  • A. Stránsky
    • 2
  1. 1.Dept. of NeurophysiologyPolish Academy of Sciences Medical Research CentreWarsawPoland
  2. 2.Dept. of BiophysicsC.U. Medical FacultyMartinCzechoslovakia

Personalised recommendations