Attenuation of Chemoexcitation Induced by Almitrine Bismesylate in Anaesthetized Cats

  • D. S. McQueen
  • D. B. Campbell
  • B. H. Gordon
  • Y. Evrard


During a neuropharmacological investigation on the responsiveness of cat carotid body chemoreceptors to almitrine (McQueen et al., 1989), we noted that the chemoexcitatory action of this peripheral chemoreceptor stimulant tended to be diminished by repeatedly administering 0.5 mg kg−1 i.V. of the drug. Roumy and Leitner (1981) reported that the increase in chemosensory discharge evoked by almitrine (0.75 kg−1i.v.) injected at hourly intervals in rabbits became less and less marked, “as if a kind of tachyphylaxis took place in the preparation”. Hugelin (1981, unpublished results) recorded phrenic nerve activity in anaesthetized and curarized cats and found that the increase in integrated phrenic nerve activity, measured 5 min after an injection, showed tachyphylaxis in response to repeated administration of almitrine (0.5 mg kg−1 i.V.).


Carotid Body Sodium Cyanide Locke Solution Phrenic Nerve Activity Arterial Chemoreceptor 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • D. S. McQueen
    • 1
  • D. B. Campbell
    • 2
  • B. H. Gordon
    • 2
  • Y. Evrard
    • 3
  1. 1.Department of PharmacologyUniversity of Edinburgh Medical SchoolEdinburghUK
  2. 2.Servier Research and DevelopmentFulmerUK
  3. 3.Neuilly-sur-SeineFrance

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