The Dopamine Turnover in Rat Carotid Body under Chronic Almitrine Treatment: Effects of Sinus Nerve Transection and Sympathectomy
It has long been recognized that electrical or physiological stimulation of the carotid sinus nerve (CSN) or of the sympathetic nerve fibers supplying the carotid body are able to modify the chemosensory activity (for review see O’Regan and Majcherczyk, 1983). Stimulating the CSN can induce an efferent inhibition of the chemosensory activity of the carotid body. On the other hand, the excitation of the sympathetic fibers which run along the ganglio-glomerular nerve from the superior cervical ganglion to the carotid body may produce excitatory as well as inhibitory effects on the carotid chemoreceptor activity. One hypothesis proposed to explain these efferent influences presumes that the nerve fibers exert a direct effect on the release of neurotransmitters modulating the chemosensory discharges (Mc Donald and Mitchell, 1975; Sampson et al., 1975). Catecholamines, especially dopamine (DA), have been evoked as possible candidates because DA is a potent neuromodulator of the peripheral chemosensitivity and is released during hypoxia (Hanbauer and Hellström, 1978; Llados and Zapata, 1978).
KeywordsMalic Acid Carotid Body Superior Cervical Ganglion Sympathetic Fiber Glomus Cell
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