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Effects of Hypoxia in Developing Swine

  • P. M. Gootman
  • N. Gootman
  • B. J. Buckley
  • B. J. Peterson
  • A. M. Steele
  • A. L. Sica
  • M. R. Gandhi

Abstract

Hypoxia is a complication which frequently occurs in human infants who have experienced perinatal stress. Although cardiovascular (CV) responses to hypoxia are well documented in both the fetus and adult, there is limited information about the postnatal maturation of regional circulatory responses to hypoxia, still less on the sympathetic rhythm generating systems (SRGS), as monitored by recordings of spontaneous efferent sympathetic (SAMP) activity. On the other hand, the effects of hypoxia on the developing respiratory rhythm generator (RRG) have been well documented in many species (cf. Gootman et al., 1989; Steele, 1986). In our previous studies, maturation- related responses to other stresses, i.e., hemorrhage and hypercapnia, were observed in swine (Buckley et al., 1984; Gootman et al., 1985; Reddy et al., 1974). This animal model is less mature at birth than lambs and guinea pigs, and more mature at birth than puppies, rats, and kittens (N.M. Buckley, 1983, 1986; Gootman, 1983). This paper summarizes our studies on the effects of two degrees of hypoxia on four different regional circulations and on efferent SYMP and phrenic activity in swine from birth to 2 months of age.

Keywords

Severe Hypoxia Power Spectral Analysis Moderate Hypoxia Local Cerebral Blood Flow Systemic Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • P. M. Gootman
    • 1
    • 2
  • N. Gootman
    • 1
    • 2
  • B. J. Buckley
    • 1
    • 2
  • B. J. Peterson
    • 1
    • 2
  • A. M. Steele
    • 1
    • 2
  • A. L. Sica
    • 1
    • 2
  • M. R. Gandhi
    • 1
    • 2
  1. 1.Department of PhysiologySUNY Health Sciences CenterBrooklynUSA
  2. 2.Department of PediatricsSchneider Children’s Hospital, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of MedicineNew Hyde ParkUSA

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