Oxygen Supply in the Fetal and Newborn Lamb Carotid Body

  • H. Acker
  • B. Bölling
  • F. Degner
  • J. Hilsmann


Blanco et al. (1984) showed that the carotid chemoreceptors are active and responsive to natural stimuli in the fetal sheep, but quiescent in the lamb on the day of birth when the arterial oxygen pressure has risen. The hypoxic sensitivity of chemoreceptors is reset from the fetal to the adult range over the next few days (resetting phenomenon). The basic mechanism of the resetting phenomenon is not known, but could partly be due to a change in the carotid body oxygen supply. The oxygen transport to tissue and, thus, a sufficient supply of oxygen to the tissue mainly depends on the following:
  1. 1.

    An adequate capillary network and microcirculation in the tissue and the O2 transport capacity of the blood.

  2. 2.

    Transport of oxygen by diffusion.

  3. 3.

    Oxygen pressure in tissue and its distribution.

  4. 4.

    Local oxygen consumption.

  5. 5.

    Critical mitochondrial oxygen pressure.



Carotid Body Shunt Flow Fetal Sheep Newborn Lamb Local Flow Velocity 
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  1. Acker, H, 1988, Chemoreceptor and baroreceptor control of perinatal oxygen supply in different organs, in; “Fetal and Neonatal Development,” C. T. Jones, ed., Perinatology Press, Ithaca, New York.Google Scholar
  2. Acker, H., Lübbers, D. W., Purves, M. J., and Tan E. D., 1980, Measurements of partial pressure of oxygen in the carotid body of fetal sheep and newborn lamb, J. Devel. Physiol., 2:323.Google Scholar
  3. Acker, H., and O’Regan, R. G., 1981, The effects of stimulation of autonomic nerves on carotid body blod flow in the cat, J. Physiol., 315:99.Google Scholar
  4. Barrett, S., Mulligan, E., Wagerle, L. C., and Lahiri, S., 1988, Measurement of carotid body blood flow in cats by use of radioactive microspheres, J. Appl. Physiol., 65:2484.Google Scholar
  5. Baumgärtl, H., and Lübbers, D. W., 1973, Platinum needle electrodes for Polarographie measurements of oxygen and hydrogen, in: “Oxygen Supply,” M. Kessler, D. F. Bruley, L. C. Clark, Jr., D. W. Lübbers, and I. A. Silver, eds.. Urban & Schwarzenberg, München.Google Scholar
  6. Blanco, L. E., Daves, G. S., Hanson, M. A., and McCooke, H. B., 1984, The response to hypoxia of arterial chemoreceptors in fetal sheep and newborn lambs, J. Physiol., 351:37.Google Scholar
  7. Daly, M., Lambertsen, C. J., and Schweitzer, A., 1954, Observation on the volume of blood flow and oxygen utilization of the carotid body in the cat, J. Physiol., 125:67.Google Scholar
  8. Degner, F., and Acker, H., 1986, Mathematical analysis of tissue PO2 distribution in the cat carotid body. Pflügers Arch., 407:305.CrossRefGoogle Scholar
  9. Hilsmann, J., Degner, F., and Acker, H., 1987, Local flow velocities in the cat carotid body. Pflügers Arch., 410:204.CrossRefGoogle Scholar
  10. Himmelblau, D. M., 1964, Diffusion of dissolved gases in liquids, Chem. Rev., 64:527.CrossRefGoogle Scholar
  11. Jansen, A. H., Purves, M. J., and Tan, E. C., 1980, The role of sympathetic nerves in the activitation of the carotid body chemoreceptors at birth in the sheep, J. Devel. Physiol., 2:302.Google Scholar
  12. 12.
    McDonald, D. M., and Lame, D. T., 1983, The ultrastructure and connection of blood vessels supplying the rat carotid body and carotid sinus, J. Neurocytol., 121:117.CrossRefGoogle Scholar
  13. O’Regan, R. G, Ennis, S., Kennedy, M., and Bannigan, J., 1988, Assessment of the diameter of blood vessels linking the arterial and venous systems in the carotid body of the anesthetized cat, in: “Chemoreceptors and Reflexes in Breathing: Cellular and Molecular Aspects,” S. Lahiri, R. E. Forster, R. O. Davies, A. L. Pack, eds., Oxford University Press, Oxford.Google Scholar
  14. Seidl, E., 1976, On the variability of form and vascularization of the cat carotid body, Anat. Embryol., 149:79.CrossRefGoogle Scholar
  15. Stosseck, K., Lübbers, D. W., Cottin, M., 1974, Determination of local blood flow (microflow) by electrochemically generated hydrogerx. Pflügers Arch., 348:225.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • H. Acker
    • 1
  • B. Bölling
    • 1
  • F. Degner
    • 1
  • J. Hilsmann
    • 1
  1. 1.Max-Planck-Institut für SystemphysiologieDortmund 1Germany

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