Oxygen Supply in the Fetal and Newborn Lamb Carotid Body

  • H. Acker
  • B. Bölling
  • F. Degner
  • J. Hilsmann


Blanco et al. (1984) showed that the carotid chemoreceptors are active and responsive to natural stimuli in the fetal sheep, but quiescent in the lamb on the day of birth when the arterial oxygen pressure has risen. The hypoxic sensitivity of chemoreceptors is reset from the fetal to the adult range over the next few days (resetting phenomenon). The basic mechanism of the resetting phenomenon is not known, but could partly be due to a change in the carotid body oxygen supply. The oxygen transport to tissue and, thus, a sufficient supply of oxygen to the tissue mainly depends on the following:
  1. 1.

    An adequate capillary network and microcirculation in the tissue and the O2 transport capacity of the blood.

  2. 2.

    Transport of oxygen by diffusion.

  3. 3.

    Oxygen pressure in tissue and its distribution.

  4. 4.

    Local oxygen consumption.

  5. 5.

    Critical mitochondrial oxygen pressure.



Carotid Body Shunt Flow Fetal Sheep Newborn Lamb Local Flow Velocity 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • H. Acker
    • 1
  • B. Bölling
    • 1
  • F. Degner
    • 1
  • J. Hilsmann
    • 1
  1. 1.Max-Planck-Institut für SystemphysiologieDortmund 1Germany

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