Influence of Hypercapnia on Rabbit Intrapulmonary Neuroepithelial Bodies: Microfluorimetrical and Morphometrical Study

  • A. Tierens
  • M. Decramer
  • J. Lauweryns


Neuroepithelial bodies (NEB) are organoid innervated cell clusters occurring throughout the intrapulmonary airways and extending from the basement membrane to the airway lumen1. Ultrastructurally they contain dense-cored granules (DCV) and are innervated by morphologically afferent and efferent nerve endings1,2.


Protein Gene Product Respiratory Mucosa Control Lung Basal Cell Membrane Neuroepithelial Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    J. M. Lauweryns, M. Cokelaere, and P. Theunynck, Neuroepithelial bodies in the respiratory mucosa of various mammals. A light optical, histochemical and ultrastructural investigation, Z. Zellforsch. 135:569 (1972).CrossRefGoogle Scholar
  2. 2.
    J. M. Lauweryns and A. Van Lommel, Ultrastructure of nerve endings and synaptic functions in rabbit intrapulmonary neuroepithelial bodies: a single and serial section analysis, J. Anat. 151:65 (1987).Google Scholar
  3. 3.
    J. M. Lauweryns, M. Cokelaere, and P. Theunynck, Serotonin-producing neuroepithelial bodies in rabbit respiratory mucosa. Science 180: 410 (1973).CrossRefGoogle Scholar
  4. 4.
    E. CutZy W. Chan, and N. S. Track, Bombesin, calcitonin and leu-enkephalin ixnmunoreactivity in endocrine cells of human lungs, Experientia 37:765 (1981).CrossRefGoogle Scholar
  5. 5.
    J. M. Lauweryns, L. Van Ranst, R. V. Lloyd, and O. T. O’Connor, Chromogranin in bronchopulmonary neuroendocrine cells. Immunocyto- chemical detection in human, monkey, and pig respiratory mucosa, J. Histochem. Cytochem. 35:113 (1987).CrossRefGoogle Scholar
  6. 6.
    J. M. Lauweryns and L. Van Ranst, Protein gene product 9.5 expression in the lungs of humans and other mammals. Immunocytochemical detection in neuroepithelial bodies, neuroendocrine cells and nerves, Neurosci. Lett. 85:311 (1988).CrossRefGoogle Scholar
  7. 7.
    J. M. Lauweryns, V. de Bock, P. Guelinckx, and M. Decramer, Effects of unilateral hypoxia on neuroepithelial bodies in rabbit lungs, J. Appl. Physiol. 55:1665 (1983).Google Scholar
  8. 8.
    J. M. Lauweryns, V. de Bock, and M. Decramer, Effects of unilateral vagal stimulation on intrapulmonary neuroepithelial bodies, J. Appl. Physiol. 63:1781 (1987).Google Scholar
  9. 9.
    J. M. Lauweryns, M. Cokelaere, M. Deleersnijder, and M. Liebens, Intrapulmonary neuroepithelial bodies in newborn rabbits. Influence of hypoxia, hyperoxia, hypercapnia, nicotine, reserpine, L-dopa and 5HTP, Cell Tissue Res. 183:425 (1977).Google Scholar
  10. 10.
    B. Falck and C. Owman, A detailed methodological description of the fluorescence method for the cellular demonstration of biogenic amines. Acta Univ. Lund II, 7 (1965).Google Scholar
  11. 11.
    V. de Bock, Embryologische, morfologische en histofysiologische studie van de intrapulmonale neuroepitheliale lichamen van het konijn. Thesis Ed acco p. 75–76 (1987).Google Scholar
  12. 12.
    H. M. Coleridge and J. C. G. Coleridge, Reflexes evoked from the tracheobronchial tree and lungs, in: “Handbook of Physiology. The Respiratory system. Control of Breathing. Section 3, Volume II,” Am. Physiological Society, Bethesda, (1986).Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • A. Tierens
    • 1
  • M. Decramer
    • 1
  • J. Lauweryns
    • 1
  1. 1.Faculty of Medicine, Laboratory of HistopathologyCatholic University of LeuvenLeuvenBelgium

Personalised recommendations