Biochemical Analysis of Neutral Endopeptidase Activity of the Cat Carotid Body

  • G. K. Kumar
  • N. S. Cherniack
  • N. R. Prabhakar


The carotid body contains enkephalins and tachykinins1–3. Several studies have shown that these peptides may be of importance in chemoreception3–6. Mechanisms that regulate the levels of these peptides in the carotid body have not been studied. Generally, neuropeptides are degraded by specific proteases7. The enzyme-neutral endopeptidase (also called enkephalinase (E.C. is involved in the metabolism of ekephalins and tachykinins in the brain and kidney7,8.


Carotid Body Superior Cervical Ganglion Rose Bengal Neutral Endopeptidase Inhibition Characteristic 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • G. K. Kumar
    • 1
  • N. S. Cherniack
    • 1
  • N. R. Prabhakar
    • 1
  1. 1.Department of Medicine, Pulmonary DivisionCase Western Reserve UniversityClevelandUSA

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