Biochemical Analysis of Neutral Endopeptidase Activity of the Cat Carotid Body
The carotid body contains enkephalins and tachykinins1–3. Several studies have shown that these peptides may be of importance in chemoreception3–6. Mechanisms that regulate the levels of these peptides in the carotid body have not been studied. Generally, neuropeptides are degraded by specific proteases7. The enzyme-neutral endopeptidase (also called enkephalinase (E.C.188.8.131.52)) is involved in the metabolism of ekephalins and tachykinins in the brain and kidney7,8.
KeywordsCarotid Body Superior Cervical Ganglion Rose Bengal Neutral Endopeptidase Inhibition Characteristic
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