Are Chemoreceptor Neurons Dopaminergic?

  • W. Kummer


In 1983, two independent groups reported the occurrence of tyrosine hydroxylase (TH) containing primary afferent neurons in some lumbar dorsal root ganglia as well as in the glossopharyngeal and vagal sensory ganglia of the rat (Price and Mudge, 1983; Katz et al., 1983). These neurons were considered to be dopaminergic, because they lacked immunoreactivity to dopamine-ß-hydroxylase (DBH). Almost all of the glossopharyngeal TH- immunoreactive (TH-IR) neurons were shown to project to the carotid body, which favoured dopamine as the transmitter of primary chemoreceptor neurons (Katz and Black, 1986). The present study was aimed to further characterize these presumed dopaminergic chemoreceptor neurons.


Dorsal Root Ganglion Tyrosine Hydroxylase Trigeminal Ganglion Carotid Body Glyoxylic Acid 
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  1. Purness, J. B., and Costa, M., 1975, The use of glyoxylic acid for the fluorescence histochemical localization of catecholamines and 5-hydroxy-tryptamine in the whole mount preparations, Histochemistry, 41:335.CrossRefGoogle Scholar
  2. Gibbins, I. L., Furness, J. B., and Costa, M., 1987, Pathway-specific patterns of the coexistence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea pig. Cell Tissue Res., 248:417.CrossRefGoogle Scholar
  3. Katz, D. M., and Black, I. B., 1986, Expression and regulation of tyrosine hydroxylase in primary sensory neurons: relationship to target innervation in vivo, J. Neurosci., 6:983.Google Scholar
  4. Katz, D. M., Markey, K. A., Goldstein, M., and Black, I. B., 1983, Expression of catecholaminergic characteristics by primary sensory neurons in the normal adult rat in vivo, Proc. Natl. Acad. Sci. USA, 80:3526.CrossRefGoogle Scholar
  5. Kummer, W., Gibbins, I. L., and Heym, Ch., 1989, Peptidergic innervation of arterial chemoreceptors. Arch. Histol. Cytol., 52:in press.Google Scholar
  6. O’Connor, T. P. and van der Kooy, D., 1988, Enrichment of a vasoactive neuropeptide (calcitonin gene related peptide) in the trigeminal sensory projection to the intracranial arteries, J. Neurosci., 8:2468.Google Scholar
  7. Owman, C., and Santini, M., 1966, Adrenergic nerves in spinal ganglia of the cat. Acta Physiol. Scand., 68:127.CrossRefGoogle Scholar
  8. Price, J., and Mudge, A. W., 1983, A subpopulation of rat dorsal root ganglion neurons is catecholaminergic. Nature, 301:241.CrossRefGoogle Scholar
  9. Quigg, M., Elfvin, L.-G., and Aldskogius, H., 1988, Distribution of cardiac sympathetic afferent fibres in the guinea pig heart labeled by anterograde transport of wheat germ agglutinin-horseradish Peroxydase, J. Auton. Nerv. Syst., 25:107.CrossRefGoogle Scholar
  10. Santini, M., 1966, Adrenergic fibres in the feline Gasserian ganglion. Life Sci., 5:283.CrossRefGoogle Scholar
  11. de la Torre, J. C., 1980, Standardization of the SPG histofluorescence method for tissue monoamines, J. Neurosci. Meth., 3:1.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • W. Kummer
    • 1
  1. 1.Institut für Anatomie und Zellbiologie IUniversität HeidelbergHeidelbergGermany

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