Are Chemoreceptor Neurons Dopaminergic?
In 1983, two independent groups reported the occurrence of tyrosine hydroxylase (TH) containing primary afferent neurons in some lumbar dorsal root ganglia as well as in the glossopharyngeal and vagal sensory ganglia of the rat (Price and Mudge, 1983; Katz et al., 1983). These neurons were considered to be dopaminergic, because they lacked immunoreactivity to dopamine-ß-hydroxylase (DBH). Almost all of the glossopharyngeal TH- immunoreactive (TH-IR) neurons were shown to project to the carotid body, which favoured dopamine as the transmitter of primary chemoreceptor neurons (Katz and Black, 1986). The present study was aimed to further characterize these presumed dopaminergic chemoreceptor neurons.
KeywordsDorsal Root Ganglion Tyrosine Hydroxylase Trigeminal Ganglion Carotid Body Glyoxylic Acid
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- Katz, D. M., and Black, I. B., 1986, Expression and regulation of tyrosine hydroxylase in primary sensory neurons: relationship to target innervation in vivo, J. Neurosci., 6:983.Google Scholar
- Kummer, W., Gibbins, I. L., and Heym, Ch., 1989, Peptidergic innervation of arterial chemoreceptors. Arch. Histol. Cytol., 52:in press.Google Scholar
- O’Connor, T. P. and van der Kooy, D., 1988, Enrichment of a vasoactive neuropeptide (calcitonin gene related peptide) in the trigeminal sensory projection to the intracranial arteries, J. Neurosci., 8:2468.Google Scholar