The Role of Arterial Endothelial Cell Mitosis in Macromolecular Permeability
Atherosclerosis is characterized by focal areas of lipid accumulation and intimal smooth muscle cell proliferation. Atherosclerotic lesions tend to develop in preferential areas in the aortic tree,1 where transendothelial macromolecular permeability is high as indicated by an enhanced uptake of the protein-binding azo dye Evans Blue in vivo.2–4 These so-called blue areas have been shown to be associated with an increased rate of endothelial cell turnover3,5 and an enhanced permeability to low density lipoproteins (LDL).6 The subendothelial accumulation of unesterified cholesterol has been hypothesized to be an initial event in atherogenesis.7 The mechanism by which macromolecules such as LDL or albumin enter the arterial wall, however, is still not completely understood.
KeywordsEvans Blue Subendothelial Space Aortic Endothelium Open Junction Macromolecular Permeability
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