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Role of Hemodynamic Factors in Atherogenesis

  • Takeshi Karino
  • Toshihisa Asakura
  • Shoji Mabuchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)

Abstract

Clinical and postmortem studies indicate that atherosclerotic lesions on the vessel wall develop not randomly, and not everywhere in the circulation, but at particular localized sites in the arterial tree such as bifurcations, T-junctions, and curved segments of arteries where the blood flow is disturbed and formation of eddies is likely to occur. Thus, to elucidate the possible connection between blood flow and the localized genesis and development of atherosclerosis, a considerable amount of work has been carried out in recent years.1,2 Theoretically, through the development of computational techniques, it has now become possible to simulate the blood flow through various channels, but the analysis is still limited to only those vessels having oversimplified geometries. Experimentally, due to the difficulties in visualizing the detailed flow patterns in vivo, most of the flow studies have been conducted in vitro using various models of arteries3–5 and arterial molds.6–8 However, even with the high quality casting and molding techniques available today, it is still not easy to precisely duplicate the complex geometry of the vessel lumen encountered in various regions of the circulation.

Keywords

Wall Shear Stress Left Anterior Descend Recirculation Zone Pulsatile Flow Curve Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    H.L. Goldsmith and T. Karino, Mechanically induced thromboemboli, in “Quantitative Cardio vascular Studies — Clinical and Research Applications of Engineering Principles,” N.H.C. Hwang, D.R. Gross and D.J. Patel, eds., University Park Press, Baltimore, (1978).Google Scholar
  2. 2.
    G. Schettler, R. Nerem, H. Schmid-Schönbein, H. Mori and C. Diehm, eds., “Fluid Dynamics as a Localizing Factor for Atherosclerosis,” Springer-Verlag, Heidelberg (1983).Google Scholar
  3. 3.
    B.K. Bharadvaj, R.F. Mabon and D.P. Giddens, Steady flow in a model of the human carotid bifurcation, Part I — flow visualization, J. Biomechanics 15:349 (1982).CrossRefGoogle Scholar
  4. 4.
    T. Fukushima and T. Azuma, The horseshoe vortex: A secondary flow generated in arteries with stenosis, bifurcation and branchings, Biorheology 19:143 (1982).PubMedGoogle Scholar
  5. 5.
    R. Rayman, R.G. Kratky and M.R. Roach, Steady flow visualization in a rigid canine aortic cast, Biomechanics 18:863 (1985).CrossRefGoogle Scholar
  6. 6.
    S. Moravec and D. Liepsch, Flow visualization in a model of a three-dimensional human artery with Newtonian and non-Newtonian fluids. Part I, Biorheology 20:745 (1983).PubMedGoogle Scholar
  7. 7.
    O.J. Deters, F.F. Mark, C.B. Bargeron, M.H. Friedman and G.M. Hutchins, Comparison of steadyand pulsatile flow near the ventral and dorsal walls of casts of human aortic bifurcations, ASME J. Biomechanical Engineering 106:79 (1984).CrossRefGoogle Scholar
  8. 8.
    F.J. Walburn, H.N. Sabbah and P.D. Stein, Flow visualization in a mold of an atherosclerotic human abdominal aorta, ASME J. Biomechanical Engineering 103:168 (1981).CrossRefGoogle Scholar
  9. 9.
    T. Karino and M. Motomiya, Flow visualization in isolated transparent natural blood vessels, Biorheology 20:119 (1983).PubMedGoogle Scholar
  10. 10.
    T. Karino and M. Motomiya, Flow through a venous valve and its implication in thrombus formation. Thrombosis Research 36:245 (1984).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Motomiya and T. Karino, Flow patterns in the human carotid artery bifurcation. Stroke 15:50 (1984).PubMedCrossRefGoogle Scholar
  12. 12.
    M.R. Roach, The effects of bifurcations and stenoses on arterial disease, in “Cardiovascular Flow Dynamics and Measurements,” N.H.C. Hwang and N.A. Normann, eds.. University Park Press, Baltimore, pp. 489–539 (1977).Google Scholar
  13. 13.
    M.R. Roach, J.F. Cornhill and J. Fletcher, A quantitative study of the development of sudanophiliclesions in the aorta of rabbits fed a low-cholesterol diet for up to six months, Atherosclerosis 29:259 (1978).PubMedCrossRefGoogle Scholar
  14. 14.
    M.R. Roach, and J. Fletcher, Alterations in distribution of sudanophilic lesions in rabbits after cessation of a cholesterol-rich diet, Atherosclerosis 32:1 (1979).PubMedCrossRefGoogle Scholar
  15. 15.
    M.R. Roach, S. Scott and G.G. Ferguson, The homodynamic importance of the geometry of bifurcations in the Circle of Willis (glass model studies),Stroke 3:255 (1972).PubMedCrossRefGoogle Scholar
  16. 16.
    T. Karino, H.H.M. Kwong and H.L. Goldsmith, Particle flow behavior in models of branching vessels: I, vortices in 90° T-junctions, Biorheology 16:231 (1979).PubMedGoogle Scholar
  17. 17.
    T. Karino and H.L. Goldsmith, Particle flow behavior in models of branching vessels: II, effects of branching angle and diameter ratio on flow patterns,Biorheology 22:87 (1985).PubMedGoogle Scholar
  18. 18.
    J.T. Flaherty, J.E. Pierce, V.J. Ferrans, D.J. Patel, W.K. Tucker and D.L. Fry, Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events, Circ. Res. 30:23 (1972).PubMedCrossRefGoogle Scholar
  19. 19.
    C.F. Dewey, S.R. Bussolari, M.A. Gimbrone and P.F. Davies, The dynamic response of vascularendothelial cells to fluid shear stress, J. Biomech. Eng. 103:177 (1981).PubMedCrossRefGoogle Scholar
  20. 20.
    M.A. Reidy and D.E. Bowyer, Scanning electron microscopy of arteries. Atherosclerosis 26:181 (1977).PubMedCrossRefGoogle Scholar
  21. 21.
    M.J. Levesque, D. Liepsch, S. Moravec and R.M. Nerem, Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta. Atherosclerosis 6:220 (1986)Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Takeshi Karino
    • 1
  • Toshihisa Asakura
    • 1
  • Shoji Mabuchi
    • 1
  1. 1.McGill University Medical ClinicMontreal General HospitalMontrealCanada

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