Atrial Natriuretic Peptide (ANP)-Induced Increase in Capillary Albumin and Water Flux

  • Virginia H. Huxley
  • D. Joseph MeyerJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)


Circulating levels of atrial natriuretic peptide (ANP) rise in response to acute hypervolemia and during chronic conditions such as congestive heart failure or arterial hypertension.1,2,3 Intravenous infusion of the peptide depresses mean arterial blood pressure and elevates hematocrit in both normal and hypertensive subjects.4,5 Although ANP is a potent vasorelaxant and reduces peripheral vascular resistance, recent studies suggest that ANP-induced hypotension results primarily from a drop in cardiac output.6,7,8 ANP infusion reduces plasma volume in normotensive rats; which may account, at least in part, for the change in cardiac output.9,10 Investigations thus far have failed to identify a direct inotropic effect of the peptide on cardiac muscle.6


Capillary Pressure Atrial Natriuretic Peptide Atrial Natriuretic Factor Solute Flux Protein Permeability 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Virginia H. Huxley
    • 1
  • D. Joseph MeyerJr.
    • 1
  1. 1.Department of PhysiologyUniversity of Missouri-Columbia, Medical SchoolColumbiaUSA

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