Matrix Control of Tumor Angiogenesis
Tumor angiogenesis is the process through which certain tumors stimulate the growth of the microvascular network in the surrounding tissue. This capillary network is remarkable in that the growth is directed towards the tumor which becomes vascularized. An important fundamental question is, what is the nature of the molecular controls responsible for the directed vascularization? As cell migration is the salient feature in neovascularization the question thus becomes, what are the molecular events that control cell migration during neovascularization? A wide variety of compounds have been shown to be inducers of angiogenesis or neovascularization in vivo. These include both tumor or tissue derived factors as well as a number of chemical factors.1,2,3,4,5,6 All of these, with the exception fo angiogenin, have been shown to also induce endothelial cell migration.
KeywordsMigration Heparin Adenosine Retina Proline
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