Advertisement

Transvascular and Interstitial Transport in Tumors

  • Rakesh K. Jain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)

Abstract

The advent of hybridoma technology and genetic engineering has led to a large scale production of monoclonal antibodies and other biologically useful molecules. Some of these molecules can bind to intra-or extracellular sites in tumors for detection and treatment, while others (e.g., lymphokines) have the ability to activate certain immune cells for killing cancer cells. Since these molecules or cells do not have the biological selectivity for tumors in vivo as previously envisioned, methods must be developed to deliver them selectively to the target in vivo. Since no molecule or cell can reach the tumor cells without passing through the vascular and interstitial compartments, it seems reasonable to find out more about the structure and function of these two compartments. In the past few years, we have focused our research on the experimental and mathematical characterization of transport through these spaces. I would like to share the results of some of these studies with you, and point out their implications for tumor growth, detection and treatment.

Keywords

Convective Velocity Fluorescence Recovery After Photobleaching Microvascular Permeability Increase Tumor Size Tumor Periphery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    F.E. Curry, Mechanics and thermodynamics of transcapiilary exchange. In “Handbook of Physiology — The Cardiovascular System — Microcirculation,” E.M. Renkin and C.C. Michel, eds, American Physiological Society, Bethesda, pp 309–374 (1984).Google Scholar
  2. 2.
    R.K. Jain, Transport of molecules across tumor vessels. Cancer and Metastasis Reviews. 6:559–594 (1987).PubMedCrossRefGoogle Scholar
  3. 3.
    R.K. Jam, Transport of molecules in the tumor interstitium: A review. Cancer Research, 47:3038–3050 (1987).Google Scholar
  4. 4.
    R.K. Jain, Transport of macromolecules in tumor microcirculation. Biotechnology Progress, 1:81–94 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    L.J. Nugent and R.K. Jain, Monitoring transport in the rabbit ear chamber. Microvascular Research, 24:204–209 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    L.J. Nugent and R.K. Jain, Plasma pharmacokinetics and interstitial diffusion of macromolecules in a normal capillary bed, American Journal of Physiology, 246:H129-H137 (1984).PubMedGoogle Scholar
  7. 7.
    L.E. Gerlowski and R.K. Jain, Microvascular permeability of normal and neoplastic tissues, Microvascular Research, 31:288–305 (1986).PubMedCrossRefGoogle Scholar
  8. 8.
    L.J. Nugent and R.K. Jain, Extravascular diffusion in normal and neoplastic tissues, Cancer Research, 44:238–244 (1984).PubMedGoogle Scholar
  9. 9.
    L.J. Nugent and R.K. Jain, Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues, Microvascular Research, 28:270–274 (1984).PubMedCrossRefGoogle Scholar
  10. 10.
    R.K. Jain and K.A. Ward-Hartley, Dynamics of cancer cell interactions with microvasculature and interstitium, Biorheology, 24:117–125 (1987).PubMedGoogle Scholar
  11. 11.
    L.E. Gerlowski and R.K. Jain, Effect of hyperthermia on microvascular permeability of normal and neoplastic tissues. International Journal of Microcirculation: Clinical and Experimental, 4:336–372 (1985).Google Scholar
  12. 12.
    H. Sezaki and M. Hashida, Macromolecule — drug conjugates in targeted cancer chemotherapy, CRC Critical Reviews on Therapeutic Drug Systems, 1:1–38 (1984).Google Scholar
  13. 13.
    G. Poste, Drug targeting in cancer therapy In: “Receptor-Mediated Targeting of Drugs,” G. Gregoriadis, G. Poste, J. Senior and A. Trouet, eds, Plenum, New York, pp. 427–474 (1985).Google Scholar
  14. 14.
    R.K. Jain, J. Weissbrod and J. Wei, Mass transfer in tumors: Characterization and applications in chemotherapy,Advances in Cancer Research, 33:251–310 (1980).PubMedCrossRefGoogle Scholar
  15. 15.
    L.E. Gerlowski and R.K. Jain, Physiologically-based pharmacokinetics: Principles and applications, Journal of Pharmaceutical Sciences, 72:1103–1127 (1983).PubMedCrossRefGoogle Scholar
  16. 16.
    R.K. Jain and K.A. Ward-Hartley, Tumor blood flow: Characterization, modifications and role in hyperthermia, IEEE Transactions in Sonics and Ultrasonics; Special Issue on Hyperthermia, SU-31:504–526 (1984).Google Scholar
  17. 17.
    R.K. Jain and J. Wei, Dynamics of drug transport in solid tumors: Distributed parameter model,J. Bioengineering, 1:313–329 (1977).Google Scholar
  18. 18.
    R.K. Jain, Intersitital transport in tumors,Advances in Microcirculation. 13:266–284 (1987).Google Scholar
  19. 19.
    T.B. Butler, F.H. Grantham and P.M. Gullino, Bulk transfer of fluid in the interstitial compartment,Cancer Research, 35:512–516 (1975).PubMedGoogle Scholar
  20. 20.
    D.L. Taylor, A.S. Waggoner, R.F. Murphy, F. Lanni, and R.R. Birge, eds., “Applications of fluorescence in the biomedical sciences,” A.R. Liss, New York (1986).Google Scholar
  21. 21.
    S.C. Chary and R.K. Jain, Analysis of diffusive and convective recovery after photobleaching — uniform flow field. Chemical Engineering Communications. 55:235–249 (1987).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Rakesh K. Jain
    • 1
  1. 1.Department of Chemical EngineeringCarnegie Mellon UniversityPittsburghUSA

Personalised recommendations