Endothelial Cell Function in Hemostasis and Thrombosis
The endothelium comprises a single layer of polygonal cells lining the entire length of blood vessels. It plays a pivotal role in modulating a number of physiologic and pathophysiologic processes including hemostasis, thrombosis, inflammation and immune responses.1 This review will focus on the endothelial cell function in hemostasis and thrombosis. Hemostasis is a complex event involving multiple interactions between blood cells and the damaged vessel wall, the coagulation proteins and blood cell constituents and the cell-cell interactions. These complex biologic processes generally do not occur without endothelial damage. Intact endothelium appears to function not only as a physical barrier which blocks active interaction between the cellular and protein constituents of blood and the vessel wall but also as a biologically active tissue capable of synthesizing compounds that promote and control hemostatic function. Moreover, its surface possesses specific properties for modulating certain key reactions in the coagulation cascade.
KeywordsEndothelial Cell Plasminogen Activator Tissue Factor Platelet Adhesion Fibrinolytic Activity
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