Enzymatic Properties in Pericellular Membranes of Leukemic Cells

  • Gabriele Losa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 145)


Many of the physiological events taking place at the cell surface, as for example ion and amino acid transport between the external and inside cell compartment, membrane rearrangement, transfer of hormonal and other stimuli, are carried out and regulated by enzymes tightly associated to the plasma membrane. Thanks to their location such enzymes are considered specific markers of the plasmalemmal component and reliable indicators of its physiological state, as shown by Beaufay et al.1. Therefore changes in their activities could account for the biochemical alterations occurring in the plasma membrane of peripheral blood cells during the malignant proliferation. The aim of this study was to distinguish the various types of acute leukemias by analyzing biochemically the enzyme characteristics of the plasma membrane in cell populations isolated from the peripheral blood of leukemic patients.


Acute Myeloid Leukemia Acute Leukemia Terminal Deoxynucleotidyl Transferase Total Reaction Volume Nylon Fiber 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Gabriele Losa
    • 1
  1. 1.Laboratory of Cellular PathologyTicino Institute of PathologyLocarnoSwitzerland

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