The Bollum Enzyme in Leukemia and Lymphoma Cells: The First Decade
It is now almost a decade since the original report of the presence of the Bollum enzyme (terminal deoxynucleotidyl transferase, TdT) in leukemia cells1. That discovery was a fortuitous event which occurred in the course of experiments characterizing what at first appeared to be tumor virus reverse transcriptase in the blast cells of a child with acute lymphoblastic leukemia1,2. The restricted expression of terminal transferase in normal cells had been reported one year earlier by Lucy Chang, working in Fred Bollum’s laboratory3. We interpreted our observation in the light of this restricted expression, postulating that TdT-positive leukemic cells were clonal expansions of TdT-positive normal cell compartments1,4.
KeywordsAcute Lymphoblastic Leukemia Chronic Myelogenous Leukemia Blast Cell Lymphoblastic Lymphoma Severe Combine Immunodeficiency Disease
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