Advertisement

Effect of Nucleosides on Human T and B Lymphoblastoid Cell Lines

  • D. Breviario
  • P. Plevani
  • N. Sacchi
  • G. Badaracco
  • U. Bertazzoni
  • E. Ginelli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 145)

Abstract

Human T and B lymphoblastoid cell lines have been used as model systems to study the biochemical basis of some immune disfunctions, associated to specific purine metabolic enzyme deficiencies (1,2).

Keywords

Terminal Deoxynucleotidyl Transferase Lymphoblastoid Cell Line Biochemical Basis Terminal Transferase Human Myeloid Leukemic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    E. R. Giblett, J. E. Anderson, F. Cohen, B. Pollara and H. F. Meuwissen, Adenosine deaminase deficiency in two patients with severely impaired cellular immunity, Lancet 2:1067 (1972)PubMedCrossRefGoogle Scholar
  2. 2.
    E. R. Giblett, A. J. Amman, D. W. Wara and L. K. Diamond, Nucleoside Phosphorylase deficiency in a child with severely impaired T-cell immunity and normal T-cell immunity. Lancet 1:1010 (1975).PubMedCrossRefGoogle Scholar
  3. 3.
    D. A. Carson, J. Kaye, S. Matsumoto, J. E. Seegmiller and L. Thompson, Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines, Proc.Natl.Acad.Sci. 76: 2430 (1980).CrossRefGoogle Scholar
  4. 4.
    R. L. Wortmann, B. S. Mitchell, N. L. Edwards and I. H. Fox, Biochemical basis for differential deoxyadenosine toxicity to T and B lymphoblasts: Role for 5’-nucleotidase, Proc.Natl.Acad,Sei (USA) 76: 2434 (1979).CrossRefGoogle Scholar
  5. 5.
    F. J. Bollum and I. Goldschneider, Membranes, Receptors and the immune response, in “Progress in Clinical and Biological Research” (Cohen, E. R, and Köhler H. eds.) Alan R. Liss Inc., New York (1980) vol. 42, pp. 189–202.Google Scholar
  6. 6.
    F. J. Bollum, Terminal deoxynucleotidyl transferase as a hematopoietic cell marker. Blood 54:1203 (1979).PubMedGoogle Scholar
  7. 7.
    K. E. Gregoire, I. Goldschneider, R. W. Barton and F. J. Bollum, Ontogeny of terminal deoxynucleotidyl transferase positive cells in l3miphopoietic tissues of rat and mouse, J. Immunol. 123:1347 (1979).PubMedGoogle Scholar
  8. 8.
    F. J. Bollum, Terminal deoxynucleotidyl transferase: Biological studies, in “Advance in Enzymology” (Meister A. ed.) Wiley Interscience, New York, pp. 347 (1978).Google Scholar
  9. 9.
    F. J. Bollum, Terminal transferase: experienced biochemical reagent seeks biological assignment. TIBS, February: 41 (1981).Google Scholar
  10. 10.
    A. Cohen, J. W. W. Lee, H. M. Dosch and E. Gelfand, The expression of deoxyguanosine toxicity in T lymphocytes at different stages of maturation. J. Immunol. 125: 1578 (1980).PubMedGoogle Scholar
  11. 11.
    B. C. Huang, Y. Hou, L. K. Woods, G. E, Moore and T. Minowada, Cytogenetic study of human, lymphoid T cell lines derived from lymphocytic leukemia, J. Natn. Cancer Inst. 53: 665 (1974).Google Scholar
  12. 12.
    S. J. Collins, R. C. Gallo and R. E. Gallagher, Continous growth and differentiation of human myeloid leukemic cells in suspension. Nature, 270: 347 (1977).PubMedCrossRefGoogle Scholar
  13. 13.
    L. Kuehl, Isolation of skeletal muscle nuclei, Exp. Cell Res. 91: 441 (1975).PubMedCrossRefGoogle Scholar
  14. 14.
    T. M. Shinnick, E. Lund and O. Smithes, Hybridization of labelled RNA to DNA in agarose gels. Nucleic Acids Res. 2: 1911 (1975).PubMedCrossRefGoogle Scholar
  15. 15.
    E. M. Southern, Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98: 503 (1975).PubMedCrossRefGoogle Scholar
  16. 16.
    S. Ottolenghi, B. Giglioni, P. Comi, A. M. Gianni, E. Polli, C. T. A. Acquaye, J. H. Oldham and G. Masera, Globin gene deletion in HPFH, thalassaemia and Hb lepore desease. Nature 278: 654 (1979).PubMedCrossRefGoogle Scholar
  17. 17.
    D. C. Tiemeier, S. M. Tilghman and P. Leder, Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene 2: 173 (1977).PubMedCrossRefGoogle Scholar
  18. 18.
    E. Ullu and M. L. Melli, unpublished results.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. Breviario
    • 1
  • P. Plevani
    • 2
  • N. Sacchi
    • 1
  • G. Badaracco
    • 2
  • U. Bertazzoni
    • 3
  • E. Ginelli
    • 1
  1. 1.Istituto di Biologia GeneraleUniversità di MilanoItaly
  2. 2.Istituto di BiologiaEULOBresciaItaly
  3. 3.Istituto di Genetica Biochimica ed EvoluzionisticaC.N.R.PaviaItaly

Personalised recommendations