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Terminal Deoxynucleotidyl Transferase in Human Fetal Tissues

  • Claudio Casoli
  • Antonio Bonati
  • Riccardo Starcich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 145)

Summary

The authors have investigated terminal deoxynucleotidil transferase (TdT) activity in the spleen, liver and thymus of a human foetus of 23 weeks. TdT significant levels have been found and two different molecular forms were defined in each tissue.

Keywords

Spleen Cell Fetal Tissue Terminal Deoxynucleotidyl Transferase Mouse Bone Marrow Terminal Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    GREENWOOD M.F., COLEMAN M.S., HUTTON J.J., LAMPKIN B., KRILL C., BOLLUM F.J. and HOLLAND P., Terminal deoxynucleotidyl transferase distribution in neoplastic and haemopoietic cells. J. Clin. Invest., 59 (1977) 889–899.PubMedCrossRefGoogle Scholar
  2. 2.
    MEYSKENS F, L., KIETER C. A. and JONES J., Postnatal expression of terminal deoxynucleotidyl transferase (TdT) in human thymus, Blood 52 suppl. 1 (1978) (Abstract) 137.Google Scholar
  3. 3.
    YASMINEH W.G., SMITH B.M. and BLOOMFIELD C.D., DNA nucleotidylexotransferase of normal persons and leukemic patients, Clin. Chem. 26 (1980) 891–895.PubMedGoogle Scholar
  4. 4.
    HOFFBRAND A.V., GANESHAGURU K., JANOSSY G., GREAVES M.F., CATOVSKY D. and WOODRUFF R.K., Terminal deoxynucleotidyl transferase levels and membrane phenotypes in diagnosis of acute leukaemia, Lancet 2 (1977) 520–523.PubMedCrossRefGoogle Scholar
  5. 5.
    KUNG P.C., LONG J.C., McCAFFREY R. P., RATLIFF R. L., HARRISON T. A. and BALTIMORE B. S. D., Terminal deoxynucleotidyl transferase in the diagnosis of leukemia and malignant lymphoma. Am. J. Med. 64 (1978) 788–794.PubMedCrossRefGoogle Scholar
  6. 6.
    CHANG L.M.S., Development of terminal deoxynucleotidyl transferase activity in embryonic calf thymus gland, Biochem. Biophys. Res. Commun. 44 (1971) 124–131.CrossRefGoogle Scholar
  7. 7.
    SUGIMOTO M. and BOLLUM F.J., Terminal deoxynucleotidyl transferase (TdT) in cick embryo lymphoid tissues, J. Immunol. 122 (1979) 392.PubMedGoogle Scholar
  8. 8.
    GREGOIRE K.E., GOLDSCHNEIDER I., BARTON R.W. and BOLLUM F.J., Ontogeny of terminal deoxynucleotidyl transfe- rase-positive cells in lymphohemopoietic tissues of rat and mouse, J. Immunol. 123 (1979) 1347.Google Scholar
  9. 9.
    BOYUM A., Separation of leucocytes from blood and bone marrow, Scand. J. Clin. Lab. Invest. 21 suppl. 97 (1968) 1.Google Scholar
  10. 10.
    MCCAFFREY F., SMOLER D.F. and BALTIMORE D., Terminal deoxynucleotidyl transferase in a case of childhood acute lymphoblastic leukemia, Proc. Natl. Acad. Sci. U.S.A 70 (1973) 521.PubMedCrossRefGoogle Scholar
  11. 11.
    BHALLA R.B., SCHWARTZ M.K. and MODAK M.J., Selective inhibition of terminal deoxynucleotidyl transferase (TdT) by adenosine ribonucleoside triphosfate (ATP) and its application in the detection of TdT in human leukemia, Biochem. Biophys. Res. Commun. 76 (1977) 1056.Google Scholar
  12. 12.
    HUTTON J.J., COLEMAN M.S., KENEKLIS T.P. and BOLLUM F.J., Terminal deoxynucleotidyl transferase as a tumor cell marker in leukemia and lymphoma. Results from 1000 patients. In Advances in Medical Oncology. Research and Education. Vol. 4: Biological Basis for Cancer Diagnosis. Edited by M. Fox. Pergamon Press, Oxford (1979) Pp. 165–175.Google Scholar
  13. 13.
    GOLDSCHNEIDER I., AHMED A.F., BOLLUM F.J. and GOLDSTEIN A.L., Induction of terminal deoxynucleotidyl transferase and Lyt antigens in mouse bone marrow and spleen cells with thymosin: Identification of multiple subsets of prothymocytes, Manuscript submitted for publication.Google Scholar
  14. 14.
    BARAK Y., KAROV Y., LEVIN S., SOROKER N., BARASH A., LANCET M. and NIR E., Granulocyte-macrophage colonies in cultures of human fetal liver cells: morphologic and ultrastructural analysis of proliferation and differentiation. Exp. Hematol. 8 (1980) 837.PubMedGoogle Scholar
  15. 15.
    McCAFFREY R., HARRISON T.A., PARKMAN R. and BALTIMORE D., Terminal Deoxynucleotidyl Transferase Activity in Human Leukemic Cells and in Normal Thymocytes. New England Journal of Medicine 292 (1975) 775–780.Google Scholar
  16. 16.
    KUNG P.C., SILVERSTONE A.E., McCAFFREY R. P. and BALTIMORE, D., Murine terminal deoxynucleotidyl transferase: cellular distribution and response to cortisone. Journal of Experimental Medicine 141 (1975) 855–865.PubMedGoogle Scholar
  17. 17.
    PENIT C. and CHAPEVILLE F.: Developmental changes in terminal deoxynucleotidyl transferase of the chicken thymus. Biochem. Biophys. Res. Commun. 74 (1977) 1096.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Claudio Casoli
    • 2
  • Antonio Bonati
    • 1
  • Riccardo Starcich
    • 1
  1. 1.Istituto di Patologia Speciale MedicaItaly
  2. 2.Istituto di Microbiologiadell ’Universita di ParmaParmaItaly

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