Ontogeny of Terminal Deoxynucleotidyl Transferase Containing Lymphocytes in Rats and Mice

  • Irving Goldschneider
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 145)


In the classic publication by L. Chang (1), the ontogenetic appearance of terminal deoxynucleotidyl transferase (TdT) was documented in the calf thymus by enzymatic analysis. TdT activity was also found in the thymus of pig, rat, rabbit, and chicken. Subsequently, TdT has been identified in high concentrations in the thymus and, in much lower concentrations, in the bone marrow of mice and human beings (2–4). Recently, minor populations of TdT-bearing cells have been demonstrated in bone marrow, spleen, liver, lung and blood of rats and mice by a sensitive and highly specific immunofluorescence assay (5–8). This technique has not only permitted direct quantification of TdT+ cells, but it has facilitated the study of their morphology, antigenic properties and anatomical distribution.


Bone Marrow Cell Adenosine Deaminase Terminal Deoxynucleotidyl Transferase Mouse Bone Marrow Purine Nucleoside Phosphorylase 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Irving Goldschneider
    • 1
  1. 1.Department of PathologyUniversity of Connecticut Health CenterFarmingtonUSA

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