Ion-Exchange Equilibrium, Thermodynamics, and Sorption Selectivity of Organic and Physiologically Active Substances
Selective interaction with ionites is at the heart of sorption ion-exchange separation of organic and particularly physiologically active substances. This is true not only for static sorption, but also for the dynamic frontal processes. When constructing a theory for the equilibrium dynamics of ion-exchange sorption, the selectivity constants and sorption limiting capacity are major factors in the criteria defining the efficiency of a process. Finally, even in non-equilibrium dynamic sorption, selectivity, together with kinetic and hydrodynamic parameters and the dimensions of the columns, is an important indicator of i) whether a substance can be separated, ii) the yield on desorption, and iii) the concentration in the eluant. When considering the ion-exchange sorption of organic ions, especially complex ones like those of physiologically active substances, we must take into account the size of the ions, the complex polyfunctional interactions with the ionite, the morphological and electrochemical properties of the ionite, and other features of the ionites, the counter-ions, and the liquid medium in which the heterogeneous ion-exchange occurs.
KeywordsSorption Capacity Exchange Capacity Ionogenic Group Sorption Selectivity Weak Electrolyte
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