Age-Related Changes in Penile Erections and Circulating Testosterone in Middle-Aged Male Rats

  • Gary D. Gray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 113)


This symposium has documented a variety of neural and endocrine changes associated with the process of aging. The present chapter focuses on a specific behavioral consequence of these neuroendocrine changes. The behavior is penile erection. It has long been recognized that the erection response in human males declines with increasing age although this was first described systematically by Kinsey, Pomeroy and Martin (1948). Yet, the factors which account for the decline are poorly understood. One possible factor is testicular dysfunction, and innumerable sages, alchemists, and doctors have attempted to restore potency in aging men by administering testicular products, with varying degrees of success.


Plasma Testosterone Penile Erection Testosterone Enanthate Silastic Capsule Behavioral Decline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Davidson, J.M. (1977). Neurohormonal bases of male sexual behavior. In: Reproductive Physiology II, International Review of Physiology, Vol. 13, pp. 225–254. Ed. R.O. Greep. Baltimore: University Park Press.Google Scholar
  2. Davidson, J.M. Gonadal hormones and human behavior. In: Hormonal Contraceptives, Estrogen and Human Welfare. Eds. M.C. Diamond and C.C. Korenbrot. New York: Academic Press. (in press)Google Scholar
  3. Davidson, J.M., Stefanick, M.L., Sachs, B.D. and Smith, E.R. Role of androgen in sexual reflexes of the male rat. Physiol. and Behav. (in press)Google Scholar
  4. Finch, C.E. (1976). The regulation of physiological changes during mammalian aging. Q. Rev. Biol. 51, 49–83.PubMedCrossRefGoogle Scholar
  5. Gray, G.D. Changes in the levels of luteinizing hormone and testosterone in the circulation of aging male rats. J. Endocr. (in press)Google Scholar
  6. Hart, B.L. (1967). Testosterone regulation of sexual reflexes in spinal male rats. Science 155, 1282–1284.Google Scholar
  7. Hart, B.L. (1968). Sexual reflexes and mating behavior in the male rat. J. comp. physiol. Psychol. 65, 453–460.PubMedCrossRefGoogle Scholar
  8. Kinsey, A.C., Pomeroy, W.B. and Martin, C.E. (1948). Sexual Behavior in the Human Male. Philadelphia: Saunders.Google Scholar
  9. Pirke, K.M. and Doerr, P. (1970). Age-related changes in free plasma testosterone, dihydrotestosterone and oestradiol. Acta Endocr. 80, 171–178.Google Scholar
  10. Rodgers, C. and Alheid, G. (1972). Relationship of sexual behavior and castration to tumescence in the male rat. Physiol. and Behav. 9, 581–584.CrossRefGoogle Scholar
  11. Sachs, B.D. and Garinello, L.D. Interaction between penile reflexes and copulation in male rats. J. comp. physiol. Psychol. (in press).Google Scholar
  12. Smith, E.R., Damassa, D.A. and Davidson, J.M. (1977). Hormone administration: peripheral and intracranial implants. In: Methods in Psychobiology, Vol. III, pp. 259–279. Ed. R.D. Myers. New York: Academic Press.Google Scholar
  13. Stearns, E.L., MacDonnell, J.A., Kaufman, B.J., Padua, R., Lucman, T.S., Winter, J.S.D. and Faiman, C. (1974). Declining testicular function with age. Am. J. Med. 57, 761–766.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Gary D. Gray
    • 1
  1. 1.Department of PhysiologyStanford University School of MedicineStanfordUSA

Personalised recommendations