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Some Neuroendocrine Aspects of Aging

  • James A. Clemens
  • Ray W. Fuller
  • Norris V. Owen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 113)

Abstract

Many of the early studies on aging of the endocrine system were preoccupied with determining if senile changes in pituitary target organs were intrinsic to those organs or due to age-related changes in the pituitary gland. More recent studies suggest that the failure of endocrine organs may not be attributed to intrinsic changes in these organs or even senility of the pituitary gland, but rather to changes at some higher neural center that exerts a regulatory influence on pituitary tropin hormone secretion. Considerable emphasis is currently being placed on the hypothalamus as a center that may fail during the aging process, resulting in a cascading series of events that eventually lead to the senescence of endocrine organs as well as other parts of the body.

Keywords

Luteinizing Hormone Prolactin Secretion Luteinizing Hormone Level Gonadotropin Secretion Serum Prolactin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ascheim, P. (1961). La poseudogestation a repetition ches les rattes seniles. C.R. Aead. Sci. (Paris) 253: 1988–1933.Google Scholar
  2. Ascheim, P. (1976). Aging in the hypothalamic-hypophyseal ovarian axis in the rat. In: Hypothalamus Pituitary and Aging. pp. 376–418. Eds. A.V. Everitt, and J.A. Burgess, Charles C. Thomas, Springfield. Google Scholar
  3. Beck, W., Engelbart, S., Gelato, M. and Wuttke, W. (1977). Anti-gonadotrophic effect of prolactin in adult castrated and in immature female rats. Acta endocr. 84, 62–71.PubMedGoogle Scholar
  4. Bohnet, H.G., Dahlen, H.G., Schneider, H.P.G. (1974). Hyperpro-lactinemia and pulsatile LH fluctuation. Acta endocr. (Supp) 184, 109.Google Scholar
  5. Bohnet, H.G., Dahlen, H.G. Wuttke, W. and Schneider, H.P.G. (1976). Hyperprolactinemic anovulatory syndrome. J. clin. Endocr. Metab. 42, 132–143.PubMedCrossRefGoogle Scholar
  6. Bloch, S. (1961). Investigations of genital aging of female rats. Gerontologia 5, 55–62.CrossRefGoogle Scholar
  7. Clemens, J.A., Amenomori, Y., Jenkins, T. and Meites, J. (1969). Effects of hypothalamic stimulation, hormones, and drugs on ovarian function in old female rats. Proc. Soc. exp. Biol. Med. 132, 561–563.PubMedGoogle Scholar
  8. Clemens, J.A. and Bennett, D.R. (1977). Do aging changes in thepreoptic area contribute to loss of cyclic endocrine function? J. Geront. 32, 19–24.PubMedCrossRefGoogle Scholar
  9. Clemens, J.A., Smalstig, E.B. and Shaar, C.J. (1975). Inhibition of prolactin release by lergotrile mesylate: mechanism of action. Acta endocr.73, 230–237.Google Scholar
  10. Coble, Y.D., Jr., Kohler, P.O., Cargille, C.M. and Ross, G.T. (1969). Production rates and metabolic clearance rates of human FSH in pre-menopausal and post-menopausal women. J. clin. Invest. 48, 359–363.PubMedCrossRefGoogle Scholar
  11. Corrodi, H., Fuxe, K., Hokfelt, T., Lidbrink, P., and Ungerstedt, U. (1973). Effect of ergot drugs on central catecholamine neurons: evidence for a stimulation of central dopamine neurons. J. Pharm. Pharmac. 25, 409–412.CrossRefGoogle Scholar
  12. Cote, L.J. and Kremzner, L.T. (1974). Changes in neurotransmitter svstems with increasing age in human brain, In: Transactions of the American Society for Neurochemistry. 5 th Annual Meeting, p. 83.Google Scholar
  13. Cotzias, G., Miller, S.T., Tang, L.C., Papavasiliou, P.S. and Wang, Y.Y. (1977). Levodopa, fertility and longevity. Science 196, 549–551.PubMedCrossRefGoogle Scholar
  14. del Pozo, E., Varga, L., Schulz, K.D., Kunziz, H.J., Marbach, P., del Campo, G.L. and Eppenberger, U. (1975). Pituitary and ovarian response patterns to stimulation in the postpartum and in galactorrhea-amenorrhea: The role of prolactin. Ob. Gyn. 46, 539–543.Google Scholar
  15. Fuller, R.W. and Perry, K.W. (1978). Res. Comm. Chem. Path. Pharmac. (in press).Google Scholar
  16. Grandison, L., Advis, J., Hodson, C., Simpkins, J. and Meites, J. (1976). Effects of prolactin on postcastration LH release. ICRS Med. Sci. 4, 427.Google Scholar
  17. Huang, H.H., Marshal, S. and Meites, J. (1976). Induction of estrous cycles in old non-cyclic rats by progesterone, ACTH, ether stress or L-DOPA. Neuro endocrinology 20, 21–34.Google Scholar
  18. Hughes, J.R., Williams, J.G. and Currier, R. (1976). An ergot alkaloid preparation (Hydergine®) in the treatment of dementia: Critical review of the literature. J. Am. Geriat. Soc. 24, 490–497.PubMedGoogle Scholar
  19. Kohler, P.O., Ross, G.T. and Odell, W.D. (1968). Metabolic clearance and production rates of human luteinizing hormone in pre- and post-menopausal women. J. clin. Invest. 47, 38–47.PubMedCrossRefGoogle Scholar
  20. Linnoila, Markku, and Cooper, R.L. (1976). Reinstatement of vaginal cycles in aged female rats. J.Pharmac. exp. Ther. 199, 477–482.Google Scholar
  21. Lu, K.H., Chen, H.T., Grandison, L., Huang, H.H. and Meites, J. (1976). Reduced luteinizing hormone release by synthetic luteinizing hormone-releasing hormone (LHRH) in postpartum lactating rats. Endocrinology 98, 1235–1240.PubMedCrossRefGoogle Scholar
  22. Lu, K.H., Huang, H.H., Chen, H.T., Kurcz, M., Mioduszewski, R. and Meites, J. (1977). Positive feedback by estrogen and progesterone on LH release in old and young rats. Proc. Soc. exp. Biol. Med. 154, 82–85.PubMedGoogle Scholar
  23. McGeer, E.G., Fibiger, H.C., McGeer, P.L. and Wickson, V. (1971). Aging and brain enzymes. Exp. Geront. 6, 391–396.CrossRefGoogle Scholar
  24. Miller, A.E., Shaar, C.J. and Riegle, G.D. (1976). Aging effects on hypothalamic dopamine and norepinephrine content in the male rats. Exp. Aging Res. 2, 475–480.PubMedCrossRefGoogle Scholar
  25. Niswender, G.D., Midgley, A.R., Jr., Monroe, J.E. and Reichert, L.E., Jr. (1968). Radioimmunoassay of rat luteinizing hormone with anti-ovine LH serum and ovine LH-131I*. Proc. Soc. exp. Biol. Med. 128, 807–811.PubMedGoogle Scholar
  26. Peluso, J.J., Steger, R.W. and Hafez, E.S.E. (1977). Regulation of LH secretion in aged female rats. Biol. Repro. 16, 212–215.CrossRefGoogle Scholar
  27. Pepperell, R.J., Bright, M. and Smith M.A. (1977). Serum prolactin levels in normal women and in women with disorders of menstruation. Med. J. Aust. 1, 85–89.PubMedGoogle Scholar
  28. Pepperell, R.J., Evans J.H. , Brown, J.B., Bright, M.A., Smith, M.A., Burger, H.G. and Healy, D. (1977). A study of the effects of bromocryptine on serum prolactin, follicle stimulating hormone and luteinizing hormone and on ovarian responsiveness to exogenous gonadotropins in anovulatory women. Br. J. Ob. Gyn. 84, 456–463.CrossRefGoogle Scholar
  29. Reis, D.J., Ross, R.A. and Joh, T.H. (1977). Changes in the activity and amounts of enzymes synthesizing catecholamines and acetylcholine in brain, adrenal medulla, and sympathetic ganglia of aged rat and mouse. Brain Res. 136, 465–474.PubMedCrossRefGoogle Scholar
  30. Rolland, R., DeJohg, F.H., Schellekens, L.A. and Lequin, R.M. (1975). The role of prolactin in the restoration of ovarian function during the early post-partum period in the human female. Clin, endocr. 4, 27–38.CrossRefGoogle Scholar
  31. Sherman, B.M. and Korenman, S.G. (1975). Hormonal characteristics of the human menstrual cycle throughout reproductive life. J. din. Invest. 55, 699–706.Google Scholar
  32. Sherman, B.M., West J.H. and Korenman, S.G. (1976). The menopausal transition: Analysis of LH, FSH, estradiol and progesterone concentrations during the menstrual cycles of older women. J. clin. Endoor. 42, 629–636.CrossRefGoogle Scholar
  33. Simpkins, J.W., Mueller, G.P., Huang, H.H. and Meites J. (1977). Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats; Possible relation to gonadotropin secretion. Endocrinology 100, 1672–1678.PubMedCrossRefGoogle Scholar
  34. Thorner, M.O., McNeilly, A.S., Hagan, C. and Besser, G.M. (1974). Long-term treatment of galactorrhea and hypogonadism with bromocriptine.Br. Med. J. 2, 419–422.PubMedCrossRefGoogle Scholar
  35. Treolar, A.E., Boynton, R.E., Behn, B.G. and Brown, B.W. (1967). Variation of the human menstrual cycle through reproductive life.Int. J. Fert. 12, 77–126.Google Scholar
  36. Tsai, C.C. and Yen S.S.C. (1971). Acute effects of intravenous infusion of 17ß-estradiol on gonadotropin release in pre-and post-menopausal women. J. clin. Endocr. Metab. 32, 766–771.PubMedCrossRefGoogle Scholar
  37. Ungerstedt, U. , Ljungberg, T., Hoffer, B. and Siggins, G. (1975). Dopaminergic supersensitivity in the striatum. Adv. Neurol. 9, 57–65.PubMedGoogle Scholar
  38. van der Shoot, O. (1976). Changing pro-oestrous surges of luteinizing hormone in aging 5-day cyclic rats. J. Endocr. 69, 287–288.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • James A. Clemens
    • 1
  • Ray W. Fuller
    • 1
  • Norris V. Owen
    • 1
  1. 1.The Lilly Research LaboratoriesIndianapolisUSA

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