Some Neuroendocrine Aspects of Aging

  • James A. Clemens
  • Ray W. Fuller
  • Norris V. Owen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 113)


Many of the early studies on aging of the endocrine system were preoccupied with determining if senile changes in pituitary target organs were intrinsic to those organs or due to age-related changes in the pituitary gland. More recent studies suggest that the failure of endocrine organs may not be attributed to intrinsic changes in these organs or even senility of the pituitary gland, but rather to changes at some higher neural center that exerts a regulatory influence on pituitary tropin hormone secretion. Considerable emphasis is currently being placed on the hypothalamus as a center that may fail during the aging process, resulting in a cascading series of events that eventually lead to the senescence of endocrine organs as well as other parts of the body.


Luteinizing Hormone Prolactin Secretion Luteinizing Hormone Level Gonadotropin Secretion Serum Prolactin Level 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • James A. Clemens
    • 1
  • Ray W. Fuller
    • 1
  • Norris V. Owen
    • 1
  1. 1.The Lilly Research LaboratoriesIndianapolisUSA

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