Age-Related Changes In Brain Catecholamines: A Synopsis Of Findings in C57BL/6J Mice and Other Rodent Models

  • Caleb E. Finch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 113)


During the past few years it has become clear that altered functions of several neurotransmitter systems occur during normal aging in short- and long-lived mammals. As will be described below and elsewhere in this symposium (Carlsson, Davies, Makman, McGee, Sladek, Wilkes) post-maturation impairments occur in dopaminergic, noradrenergic, serotonergic, and cholinergic systems. A major con- temporary issue concerns the role of neuronal loss in the reported changes. The available information on the C57BL/6J male mouse will be reviewed in depth, since at present this strain is one of the best characterized rodent models for biochemical, endocrinological and pathological changes of aging.


Male Mouse Normal Aging Estrous Cycle Median Eminence Brain Catecholamine 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Caleb E. Finch
    • 1
  1. 1.Department of Molecular Biology and the Andrus Gerontology CenterUniversity of Southern CaliforniaLos AngelesUSA

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