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Relative Quantitation of Monoamine Histofluorescence in Young and Old Non-Human Primates

  • John R. SladekJr.
  • Celia D. Sladek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 113)

Abstract

The relative content of monoamines within identified brain stem neurons in 4 and 20-year old monkeys (Macaca nemestrina) was determined with microspectrofluorometric techniques. Intraneuronal monoamine content was found to decrease with age in the locus coe-ruleus, substantia nigra and raphe and was found to be reduced further in the locus coeruleus by the presence of lipofuscin granules. These data indicate that intraneuronal monoamine content is reduced in the aged macaque.

Keywords

Substantia Nigra Locus Coeruleus Nucleus Raphe Dorsalis Pigment Granule Relative Quantitation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • John R. SladekJr.
    • 1
  • Celia D. Sladek
    • 1
  1. 1.Departments of Anatomy and NeurologyUniversity of Rochester School of MedicineRochesterUSA

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