Biogenic Amine-Stimulated Adenylate Cyclase and Spiroperidol-Binding Sites in Rabbit Brain: Evidence for Selective Loss of Receptors with Aging
The aging process in man results in or is accompanied by a host of changes in brain structure and biochemistry (Terry and Gershon, 1976). The possible relationship of these alterations to the diminished mental function seen frequently in the older population is not yet known. Furthermore, the implications of these alterations for the manifestation and severity of neurological diseases such as parkinsonism are poorly understood. A major task in the investigation of biochemical changes occurring with senescence is to sort out the early or primary changes of greatest functional significance. In this regard, it is becoming increasingly evident that biogenic amine and closely interrelated transmitter or synaptic modulator systems play important roles in hypothalamic, cortical and extrapyramidal system functions. A number of studies have indicated that in experimental animals and in man deficiencies in brain aminergic systems, assessed functionally and/or biochemically, may occur with senescence (Finoh, 1973; Finch, Jonec, Hody, Walker, Morton-Smith, Alper and Dougher, 1975; Jonec and Finch, 1975; McGeer and McGeer, 1976ab; McGeer, McGeer and Suzuki, 1977; Simpkins, Mueller, Huang and Meites, 1977) (see also Finch and McGeer in this volume).
KeywordsFrontal Cortex Dopamine Receptor Adenylate Cyclase Biogenic Amine Cyclase Activity
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