Cyclic Nucleotides in Neuroendocrine Function
Several antipsychotic agents produce extrapyramidal side effects which resemble Parkinson’s disease (Hollister, 1972; Hornykiewicz, 1973). It is generally agreed that these side effects may arise from the ability of these drugs to block the dopamine receptor of the caudate nucleus (Carlsson and Lindqvist, 1963; Nyback and Sedvall, 1968). Biochemical and pharmacological studies have suggested an intimate association between the dopamine receptor and a dopamine-sensitive adenylate cyclase in the caudate since the properties of the enzyme mimicked in large part the actions of the dopamine receptor (Kebabian, Petzold and Greengard, 1972; Clement-Cormier, Kebabian, Petzold and Greengard, 1974; Iverson, 1975; Anden and Stock, 1973).
KeywordsDopamine Receptor Anterior Pituitary Cyclase Activity Adenylate Cyclase Activity Median Eminence
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