An Endocrine Hypothesis of Brain Aging and Studies on Brain-Endocrine Correlations and Monosynaptic Neurophysiology during Aging

  • Philip W. Landfield
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 113)


As many papers in this symposium indicate, there is rapidly growing evidence that alterations in the neural regulation of endocrine functions may play a major role in mammalian aging. In particular, there seems to be a somewhat selective age-dependent deterioration of dopaminergic transmitter systems in rodents (Finch, 1973; Simpkins, Mueller, Huang and Meites, 1977) and in humans (Carlsson, this volume). Additionally, there is now some evidence that reduced dopaminergic presynaptic function is associated with reduced postsynaptic dopamine receptors in at least some systems (Severinson and Finch, unpublished; Finch, this volume). The major role which dopamine seems to play in certain well-established age-dependent syndromes, such as parkinsonism in humans (Carlsson, this volume; Barbeau, this volume) or cessation of ovarian cycling in rats (Clemens, this volume; Clemens and Bennett, 1977), as well as the apparent significance of hypothalamic dopaminergic mechanisms in endocrine regulation (reviewed in Reichlin, 1974; Schally, Arimura and Kastin, 1973; Blackwell and Guillemin, 1973), lends significant support to the view that neuroendocrine deregulation could be a critical factor in the mammalian aging process.


Reactive Astrocyte Aged Animal Stimulation Pulse Schaffer Collateral Adrenal Weight 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Philip W. Landfield
    • 1
  1. 1.Department of Physiology and PharmacologyBowman Gray School of MedicineWinston-SalemUSA

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