Age Effects on the Hypothalamic-Pituitary-Gonadal Control System in the Rat

  • G. D. Riegle
  • A. E. Miller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 113)


Early recognition that hormones were major regulators of body function has made studies of aging on endocrine control mechanisms attractive to gerontologists. Age alterations in reproductive control systems are well documented. A better understanding of aging changes in the reproductive control system of both man and other species should not only aid in the identification of appropriate animal models to use in the study of aging effects on human physiological systems, but also allow development of clinical procedures which could restore certain endocrine functions and improve the quality of life with advancing age.


Human Chorionic Gonadotropin Gonadotropin Secretion Hypothalamic Extract Pituitary Responsiveness Pituitary Gonadotropin Secretion 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • G. D. Riegle
    • 1
  • A. E. Miller
    • 1
  1. 1.Endocrine Research Unit, Department of PhysiologyMichigan State UniversityEast LansingUSA

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