Simultaneous Measurement of PO2 and Flow at the Same Locus during Seizures and Barbiturate Suppression of EEG
This is a progress report of our effort to measure local blood flow by the hydrogen clearance method and PO2 at the same point in tissue with the objective of gaining information about oxygen consumption rate. In initial trials we followed Lubber’s example that platinum electrodes polarized at -600 mV were responsive to both O2 and H2. We have found that bare palladium works equally well. This method has the effect of superimposing a H2 saturation and clearance curve on the PO2 as a baseline. While this is satisfactory in such organs as the carotid body where flow is extremely fast, in the brain, particularly in the presence of ishemic injury, a 10 to 20 minute H2 clearance is difficult to define accurately because of lack of constancy of the PO2 baseline.
KeywordsCarotid Body Local Blood Flow Polarization Voltage Pentylene Tetrazole Clearance Curve
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