Advertisement

Simultaneous Measurement of PO2 and Flow at the Same Locus during Seizures and Barbiturate Suppression of EEG

  • R. S. McFarland
  • J. H. HalseyJr.
  • D. D. Reneau
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

This is a progress report of our effort to measure local blood flow by the hydrogen clearance method and PO2 at the same point in tissue with the objective of gaining information about oxygen consumption rate. In initial trials we followed Lubber’s example that platinum electrodes polarized at -600 mV were responsive to both O2 and H2. We have found that bare palladium works equally well. This method has the effect of superimposing a H2 saturation and clearance curve on the PO2 as a baseline. While this is satisfactory in such organs as the carotid body where flow is extremely fast, in the brain, particularly in the presence of ishemic injury, a 10 to 20 minute H2 clearance is difficult to define accurately because of lack of constancy of the PO2 baseline.

Keywords

Carotid Body Local Blood Flow Polarization Voltage Pentylene Tetrazole Clearance Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. S. McFarland
    • 1
  • J. H. HalseyJr.
    • 1
  • D. D. Reneau
    • 1
  1. 1.University of Alabama Medical CenterBirminghamUSA

Personalised recommendations