Oxygen Pressure and Ictal Activity in the Cerebral Cortex of Artificially Ventilated Rats during Exposure to Oxygen High Pressure
In rats breathing spontaneously, an increase in the inspiratory O2 pressure (PI, O2) to hyperbaric values led to phasic reactions of tissue PO2 (Pt, O2) in different structures of the CNS (OGILVIE and BALENTINE, 1973; TORBATI et al., 1976). During compression, Pt, O2 initially rose. Then Pt, O2 turned over to a secondary decline. Possible mechanisms underlying this phasic PO2 response are (i) variations of gas exchange in the lungs, (ii) changes of respiratory drive (LAMBERTSEN et al., 1953), (iii) changes of blood flou in the brain and Civ) changes of O2-consump-tion in the tissue (MAYEVSKY et al., 1974). The present experiments aimed to test the guestion, to which extent changes of oxygen transport to tissue might contribute to the behaviour of Pt, O2 described above.
KeywordsOxygen Pressure ICTAL Activity Brain Cortex Ventilatory Rate Oxygen High Pressure
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