Advertisement

Oxygen Pressure and Ictal Activity in the Cerebral Cortex of Artificially Ventilated Rats during Exposure to Oxygen High Pressure

  • A. Lehmenkühler
  • D. Bingmann
  • H. Lange-Asschenfeldt
  • D. Berges
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

In rats breathing spontaneously, an increase in the inspiratory O2 pressure (PI, O2) to hyperbaric values led to phasic reactions of tissue PO2 (Pt, O2) in different structures of the CNS (OGILVIE and BALENTINE, 1973; TORBATI et al., 1976). During compression, Pt, O2 initially rose. Then Pt, O2 turned over to a secondary decline. Possible mechanisms underlying this phasic PO2 response are (i) variations of gas exchange in the lungs, (ii) changes of respiratory drive (LAMBERTSEN et al., 1953), (iii) changes of blood flou in the brain and Civ) changes of O2-consump-tion in the tissue (MAYEVSKY et al., 1974). The present experiments aimed to test the guestion, to which extent changes of oxygen transport to tissue might contribute to the behaviour of Pt, O2 described above.

Keywords

Oxygen Pressure ICTAL Activity Brain Cortex Ventilatory Rate Oxygen High Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bean, J.W., Lignell, J. and Burgess, D.W. (1972) J. Appl. Physiol. 32, 650.PubMedGoogle Scholar
  2. Bingmann, D., Lehmenkühler, A., Lange-Asschenfeldt, H. and Berges, D. (1976) Pflügers Arch. 362, R 16.Google Scholar
  3. Caspers, H., Speckmann, E.-J. (1972) Epilepsia 13, 699.PubMedCrossRefGoogle Scholar
  4. Jamieson, D. and van den Brenk, H.A.S. (1963) J. Appl. Physiol. 32, 869.Google Scholar
  5. Lambertsen, C.J., Kough, R.H., Cooper, D.Y., Emmel, G.L., Loeschcke, H.H. and Schmidt, C.F. (1953) J. Appl. Physiol. 5, 471.PubMedGoogle Scholar
  6. Lehmenkühler, A., Caspers, H. and Speckmann, E.J. (1976) A method for simultaneous measurements of bioelectric activity and local tissue PO2 in the CNS. In “Oxygen Transport to Tissue — II.” Advances in Experimental Medicine and Biology, Vol. 75 p. 3 (eds. Grote, J., Reneau, D. and Thews, G.). Plenum Press, New York.Google Scholar
  7. Mayevsky, A., Jamieson, D. and Chance, B. (1974) Brain Res. 76, 481.PubMedCrossRefGoogle Scholar
  8. Dgilvie, R.W. and Balentine, J.D. (1973) Oxygen tensions in the deep grey matter of rats exposed to hyperbaric oxygen. In “Oxygen Transport to Tissue.” Advances in Experimental Medicine and Biology, Vol. 37A, p. 299 (eds. Bicher, H. and Bruley, D.). Plenum Press, Neu York.Google Scholar
  9. Torbati, D., Parolla, D. and Lavy, S. (1976) Exp. Neurol. 50, 439.PubMedCrossRefGoogle Scholar
  10. Zoll, U.R. (1968) Dissertation, Univ. Münster, F.R.Germany.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • A. Lehmenkühler
    • 1
  • D. Bingmann
    • 1
  • H. Lange-Asschenfeldt
    • 2
  • D. Berges
    • 1
  1. 1.Physiologisches Institut der UniversitätMünsterGermany
  2. 2.Schiffahrtmedizinisches Institut der MarineKielF.R.Germany

Personalised recommendations