The Effect of Chronic Hypoxia on Wound Healing

  • C. W. Goodwin
  • R. B. Heppenstall
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


In previous work, we have examined the effect of oxygen availability on subcellular function and have established that important oxidative reactions can adapt to changes in the oxygen environment (Mela et al, 1976). This work was extended on the macroscopic level in a study which pointed out that a state of moderate hypoxia resulted in decreased new bone formation and delayed fracture healing (Heppenstall and Goodwin, 1976). In all these studies, a state of chronic hypoxia was established by a surgical vascular shunting procedure. This method presents certain advantages over models used by other investigators in that it results in an unrestrained animal with normal carbon dioxide tensions and normal acid-base balance. In the present study using this model, we examined the effects of chronic hypoxia on the tensile strength, collagen formation, and tissue oxygen tension of healing wounds.


Chronic Hypoxia Inferior Pulmonary Vein Moderate Hypoxia Hypoxic Animal Transverse Skin Incision 
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  1. Heppenstall, R. B. and Goodwin, C. W. (1976) J. Bone Joint Surg.Google Scholar
  2. Hunt, T. K. and Pai, M. P. (1972) Surg. Gynecol. Obstet. 135, 561.PubMedGoogle Scholar
  3. Hunt, T. K., Twomey, P., Zederfeldt, B., and Dunphy, J. E. (1967) Am. J. Surg. 1114 302.CrossRefGoogle Scholar
  4. Kivrikko, K. I., Laitinen, O., and Prockop, D. J. (1967) Anal. Biochem. 19, 249.CrossRefGoogle Scholar
  5. Mela, L., Goodwin, C. W., and Miller, L.D. (1976) Am. J. Physiol. 231. 1811.PubMedGoogle Scholar
  6. Schilling, J. A., Joel, W., and Shurley, H. M. (1959) Surgery 46, 702.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • C. W. Goodwin
    • 1
  • R. B. Heppenstall
    • 1
  1. 1.Departments of Surgery and Orthopedic Surgery and the Harrison Department of Surgical ResearchUniversity of PennsylvaniaPhiladelphiaUSA

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