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Effects of Ischemia on the Oxygen Diffusion Coefficients in the Brain Cortex (Studies on Macaca Irus)

  • R. Morawetz
  • E. Strong
  • D. K. Clark
  • W. Erdmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

Oxygenation of tissue is dependent both on rate and concentration of oxygen provided at the capillary level and the speed with which oxygen may diffuse from these capillaries through the tissue. Factors influencing the diffusion coefficient of oxygen in tissue include the chemical constitution of the medium, for example, protein concentration and the ratio of extracellular to intercellular volume and the density of cell membranes and other cell structures. These latter factors may be substantially modified by changes in tissue metabolism.

Keywords

Diffusion Coefficient Middle Cerebral Artery Oxygen Diffusion Brain Cortex Tissue Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Erdmann, W., Kunke, S., and Krell, W.: Tissue-PO2 and Cell Function. An Experimental Study with Multimicroelectrodes in the Rat Brain. In Oxygen Supply. Eds.Kessler, et al. Urban and Schwarzenberg, Muechen-Berlin-Wien, 1973.Google Scholar
  2. 2.
    Erdmann, W., and Krell, W.: Measurement of Diffusion Parameters with Noble Metal Electrodes. In: Oxygen Transport to Tissue — II. Eds. Grote, et al. Plenum Publishing Company, New York, 1976.Google Scholar
  3. 3.
    Clark, D.K., Erdmann, W., Halsey, J.H., and Strong, E.: Oxygen Diffusion, Conductivity and Solubility Coefficients in the Microarea of the Brain. International Symposium on Oxygen Transport to Tissue, Cambridge (England) 1977.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. Morawetz
    • 1
  • E. Strong
    • 1
  • D. K. Clark
    • 1
  • W. Erdmann
    • 1
  1. 1.Departments of Neurosurgery, Neurology, and AnesthesiologyUniversity of Alabama in BirminghamBirminghamUSA

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