Effects of Ischemia on the Oxygen Diffusion Coefficients in the Brain Cortex (Studies on Macaca Irus)
Oxygenation of tissue is dependent both on rate and concentration of oxygen provided at the capillary level and the speed with which oxygen may diffuse from these capillaries through the tissue. Factors influencing the diffusion coefficient of oxygen in tissue include the chemical constitution of the medium, for example, protein concentration and the ratio of extracellular to intercellular volume and the density of cell membranes and other cell structures. These latter factors may be substantially modified by changes in tissue metabolism.
KeywordsDiffusion Coefficient Middle Cerebral Artery Oxygen Diffusion Brain Cortex Tissue Metabolism
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- 1.Erdmann, W., Kunke, S., and Krell, W.: Tissue-PO2 and Cell Function. An Experimental Study with Multimicroelectrodes in the Rat Brain. In Oxygen Supply. Eds.Kessler, et al. Urban and Schwarzenberg, Muechen-Berlin-Wien, 1973.Google Scholar
- 2.Erdmann, W., and Krell, W.: Measurement of Diffusion Parameters with Noble Metal Electrodes. In: Oxygen Transport to Tissue — II. Eds. Grote, et al. Plenum Publishing Company, New York, 1976.Google Scholar
- 3.Clark, D.K., Erdmann, W., Halsey, J.H., and Strong, E.: Oxygen Diffusion, Conductivity and Solubility Coefficients in the Microarea of the Brain. International Symposium on Oxygen Transport to Tissue, Cambridge (England) 1977.Google Scholar