Changes in Cerebrocortical pO2 -Distribution, rCBF and EEG During Hypovolemic Shock

  • N. Wiernsperger
  • P. Gygax
  • W. Meier-Ruge
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


The prevention of the onset of irreversible damages in the brain is the primary aim in the treatment of cerebral vascular disorders. Surprisingly, the influence of hemorrhagic shock on tissue oxygenation, though it was extensively studied on various organs (Sinagowitz et al., 1973) was seldom measured in the brain. For this reason, we decided to simulate a vascular insufficiency by using the model of hypovolemic shock. Changes in blood flow in the grey matter were correlated with their consequences on tissue pO2 and EEG. In view of recent clinical results which demonstrate that disease states can disrupt the relationship between regional blood flow and oxidative metabolism (Raichle et al., 1976), we tried to improve the disturbed tissue oxygenation in two ways: a) by increasing the blood flow to the brain with a vasodilating drug (Papaverine) and b) by regulating the catecholamine metabolism with an α-adrenolytic drug,Dihydroergotoxine (Greenberg and Snyder, 1977).


Mean Arterial Blood Pressure Hypovolemic Shock Silver Silver Silver Silver Chloride Catecholamine Metabolism 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • N. Wiernsperger
    • 1
  • P. Gygax
    • 1
  • W. Meier-Ruge
    • 1
  1. 1.Department of Basic Medical ResearchSandoz LtdBaselSwitzerland

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