Changes in Cerebrocortical pO2 -Distribution, rCBF and EEG During Hypovolemic Shock
The prevention of the onset of irreversible damages in the brain is the primary aim in the treatment of cerebral vascular disorders. Surprisingly, the influence of hemorrhagic shock on tissue oxygenation, though it was extensively studied on various organs (Sinagowitz et al., 1973) was seldom measured in the brain. For this reason, we decided to simulate a vascular insufficiency by using the model of hypovolemic shock. Changes in blood flow in the grey matter were correlated with their consequences on tissue pO2 and EEG. In view of recent clinical results which demonstrate that disease states can disrupt the relationship between regional blood flow and oxidative metabolism (Raichle et al., 1976), we tried to improve the disturbed tissue oxygenation in two ways: a) by increasing the blood flow to the brain with a vasodilating drug (Papaverine) and b) by regulating the catecholamine metabolism with an α-adrenolytic drug,Dihydroergotoxine (Greenberg and Snyder, 1977).
KeywordsMean Arterial Blood Pressure Hypovolemic Shock Silver Silver Silver Silver Chloride Catecholamine Metabolism
Unable to display preview. Download preview PDF.
- 1.Enz, A., Iwangoff, P., Markstein, R., and Wagner, H. (1975) Triangel 14, 90Google Scholar
- 3.Gygax, P., Stosseck, K., Emmenegger, H., and Schweizer, A., (1975a) in “Blood Flow and Metabolism in the Brain” 11.14.(Eds Harper, A.M., Jenett, W.B., Miller, J.D., and Rowan, J.O.) Churchill, LivingstoneGoogle Scholar
- 4.Gygax, P., Hunziker, O., Schulz, U., and Schweizer, A., (1975b) Triangel 14, 80Google Scholar
- 6.Larcan, A., Streiff, F., Peters, A., and Genetet, B.(1966) Med.Pharmacol.Exp.15, 507Google Scholar
- 11.Siesjö, B.K., Johannsson, H., Ljunggren, B., and Norberg, K. (1974) in “Brain Dysfunction and Metabolic Disorders” p.75 (Ed.Plum, F.) Raven Press, New-York.Google Scholar