Flow Stasis, Blood Gases and Glucose Levels in the Red Pulp of the Spleen

  • A. C. Groom
  • M. J. Levesque
  • D. Brucksweiger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


It is known that the membrane of the red blood cell loses its extreme deformability and becomes increasingly stiff at O2 tensions below 30 mm Hg (LaCelle, 1970). Under certain conditions stasis of blood can occur within the red pulp of the spleen, and it is possible that the ensuing local hypoxia, if sufficiently severe, could lead to increased rigidity of the sequestered red cells and an acceleration of the process known as cell “conditioning” in the pulp (Griggs et al, 1960). This would be accelerated by substrate deprivation and these factors would together contribute to a shorter life-span of cells incubated within the spleen (Weed et al, 1969).


Glucose Concentration Total Blood Peripheral Venous Blood Hereditary Spherocytosis Splenic Blood Flow 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • A. C. Groom
    • 1
  • M. J. Levesque
    • 1
  • D. Brucksweiger
    • 1
  1. 1.Department of BiophysicsUniversity of Western OntarioLondonCanada

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