Flow Stasis, Blood Gases and Glucose Levels in the Red Pulp of the Spleen
It is known that the membrane of the red blood cell loses its extreme deformability and becomes increasingly stiff at O2 tensions below 30 mm Hg (LaCelle, 1970). Under certain conditions stasis of blood can occur within the red pulp of the spleen, and it is possible that the ensuing local hypoxia, if sufficiently severe, could lead to increased rigidity of the sequestered red cells and an acceleration of the process known as cell “conditioning” in the pulp (Griggs et al, 1960). This would be accelerated by substrate deprivation and these factors would together contribute to a shorter life-span of cells incubated within the spleen (Weed et al, 1969).
KeywordsGlucose Concentration Total Blood Peripheral Venous Blood Hereditary Spherocytosis Splenic Blood Flow
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- Jandl, J.H. (1967) Hereditary spherocytosis. In ‘Hereditary disorders of erythrocyte metabolism’ p.209 (ed. Beutler, E.). Grune and Stratton, New York and London.Google Scholar
- LaCelle, P.L. (1970) Seminars in Hematol. 7, 355.Google Scholar
- Levesque, M.J. and Groom, A.C. (1977) J. Lab. Clin. Med. (in press).Google Scholar
- Vaupel, P., Braunbeck, W. and Thews, G. (1973) Respiratory gas exchange and Po2 distribution in splenic tissue. In ‘Oxygen transport to tissue’ p.401 (eds. Bicher, H.I. and Bruley, D.F.) Plenum Press, New York and London.Google Scholar