Relationship between Erythropoietin Levels and Intrarenal Oxygenation during Anuric Hemorrhagic Shock
It has been shown that the kidney plays a major role in the production (Jacobson and Krantz, 1970) and perhaps inactivation (Fisher et al, 1968a) of erythropoietin (erythropoietic stimulating factor, ESF). Although most investigators believe that the renal cortex is the site controlling ESF production (Jacobson and Krantz, 1970), the evidence is not conclusive. Increase in ESF levels has been observed under a variety of stimuli including production of renal infarcts (Abbrect et al, 1966), constriction of the renal artery (Fisher et al, 1968b; Fisher and Samuels, 1967), infusion of vasopressors (Fisher et al, 1968b), hypoxic hypoxia (Murphy et al, 1971), and normovolemic anemia (Naets, 1959). However, this increase is not always present after renal arterial constriction (Murphy et al, 1967a) and hemorrhage (Murphy et al, 1967b). In addition, tissue oxygenation measurements have brought further questions about the relationship between hypoxia and ESF production (Hardwick et al, 1963). The present study was undertaken to evaluate the relationship between intrarenal oxygen availability (O2a) and consumption (VO2) and serum ESF levels during anuric hemorrhagic shock in rabbits.
KeywordsRenal Blood Flow Hemorrhagic Shock Outer Medulla Renal Infarct Erythropoietin Level
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