Respiratory Gas Transport in Blood during Pregnancy with Hemoglobin Concentrations Below 12g/100ml

  • J. Grote
  • D. Koch
  • G. Hermesdorf
  • A. Abdelhamid
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


During pregnancy the conditions for respiratory gas transport in blood and respiratory gas exchange differ from that of non-pregnant healthy women. The hemoglobin concentration and, consequently, the O2 capacity of blood decreases. The arterial CO2 tension falls between the 10th and the 40th week of gestation to values of about 30 mmHg, while the pH of the arterial blood during the same period was found to be nearly constant at an elevated level (7). Investigations of blood O2 affinity during pregnancy led to non-uniform results. Several investigators found no significant change whereas others described a significant decrease of blood O2 affinity in pregnant women and a mean P50 value of about 31 mmHg. Among the factors which are considered to influence the O2 affinity of blood, the intraerythrocytic 2,3-diphospnoglycerate concentration, in particular, increases during pregnancy (11). The aim of this study was to investigate the influence of a reduction of blood hemoglobin concentration below 12g% on the conditions for respiratory gas transport in blood of pregnant women.


Pregnant Woman Hemoglobin Concentration Anemic Patient Equilibration Curve Organic Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Astrup, P. (1956) Scand. J. clin. Lab. Invest. 8, 33 – 43PubMedCrossRefGoogle Scholar
  2. 2.
    Bauer, Ch., Ludwig, M., Ludwig, I., Bartels, H. (1969) Respir. Physiol. 7, 271 – 277PubMedCrossRefGoogle Scholar
  3. 3.
    Duhm, J. (1976) Pflügers Arch. 363, 61 – 67PubMedCrossRefGoogle Scholar
  4. 4.
    Gerlach, E., Deuticke, B. (1963) Biochem. Z. 337, 477 – 479PubMedGoogle Scholar
  5. 5.
    Grote, J. (1971) In: Nomogramme zum Säure-Basen-Status des Blutes und zum Atemgastransport (ed. Thews, G.), Anaesthesiology and Resuscitation 30, 47 – 83Google Scholar
  6. 6.
    Grote, J., Söndgen, W. (1976) Pflügers Arch. 365, R22Google Scholar
  7. 7.
    Lucius, H., Gahlenbeck, H., Kleine, H.-O., Fabel, H., Bartels, H. Respir. Physiol. 9, 311 – 317Google Scholar
  8. 8.
    Mengden, H.-J. v., Schultehinrichs, D., Thews, G. (1969) Respir. Physiol. 6, 151 – 159CrossRefGoogle Scholar
  9. 9.
    Michal, G. (1970) In: Methoden der enzymatischen Analysen (ed. Bergmeyer, H. U.) 2nd ed. 1478 – 1483Google Scholar
  10. 10.
    Niesei, W; Thews, G. (1961) Pflügers Arch. ges. Physiol. 273, 380 – 395CrossRefGoogle Scholar
  11. 11.
    Rörth, M., Bille Brahe, N. E. (1971) Scand. J. clin. Lab. Invest 28, 271 – 276PubMedCrossRefGoogle Scholar
  12. 12.
    Siggaard-Andersen, O. (1974) The acid-base status of the blood, 4th ed., Munksgaard, CopenhagenGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. Grote
    • 1
  • D. Koch
    • 1
  • G. Hermesdorf
    • 1
  • A. Abdelhamid
    • 1
  1. 1.Institute of PhysiologyUniversity of MainzGermany

Personalised recommendations