Temporal Correlations between Plasma Ovarian Steroid Hormone Levels and Intrauterine Oxygen Tension in the Guinea Pig

  • David R. Garris
  • J. A. Mitchell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


Oxygen is essential for blastocyst survival. Since, prior to implantation, the blastocyst has no direct connection with the maternal vasculature, a supply of oxygen sufficient to meet its metabolic needs must be available within the uterine lumen. In vitro studies indicate that mouse blastocysts require at least 7 mmHg of oxygen to sustain development (Auerbach and Brinster, 1968). While in vitro experiments have provided considerable information concerning conceptus metabolism and development, the environmental conditions to which the blastocyst is subjected during culture are different from the environment provided by the uterine lumen. Thus, until in vivo conditions are determined, the extent to which in vitro environments duplicate that in which blastocyst development and implantation normally occur, remains unknown.


Estrous Cycle Oxygen Availability Uterine Horn Cyclic Fluctuation Mouse Blastocyst 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • David R. Garris
    • 1
  • J. A. Mitchell
    • 1
  1. 1.Department of Anatomy, School of MedicineWayne State UniversityDetroitUSA

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