Hemoglobin-Oxygen Affinity in Organic Heart Disease

  • J. R. Neville
  • Terry Clemmer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)


In a previous communication (Neville and Clemmer, 1975) we reported that the average P50 (7.4)≠ and n* values for the oxyhemoglobin dissociation curve (ODC) in patients admitted to an intensive care unit were lower than those usually observed in healthy individuals. Only a few of the values that were obtained in this earlier study reflected a decreased hemoglobin-oxygen affinity despite the fact that many of these patients had heart disease (HD), a condition which, according to a number of investigators (Morse, et al., 1950; Metcalfe, et al., 1969; Woodson, et al., 1970; Kostuk, et al., 1973), is associated with an increased P50. Decreased oxygen affinity has not been observed in HD by all investigators, however (see Discussion); therefore, our data (Neville and Clemmer, 1975) relating to the HD patients have been analyzed separately and the results are the subject of this report.


Oxygen Transport Oxygen Affinity Heart Disease Patient Oxygen Capacity Organic Heart Disease 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. R. Neville
    • 1
  • Terry Clemmer
    • 2
  1. 1.Letterman Army Institute of ResearchPresidio of San FranciscoUSA
  2. 2.Salt Lake CityUSA

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