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Homeostatic Responses to Increased Oxygen Affinity

  • Samuel Charache
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

Oxygen transport is probably normal in carriers of hemoglobins with altered oxygen affinity, as judged by the patients’ lack of symptoms and by their excretion of normal amounts of erythropoietin (1–4). Possible adjustments to maintain homeostasis include changes in hemoglobin concentration; cardiac output, or its distribution; number of perfused capillaries (i.e., the capillary-cell distance); or oxygen utilization in the tissue (5–7). The choice between these adjustments varies from stress to stress (8); in the case of hemoglobins with altered oxygen affinity, a strong arguement was made that adjustments are almost entirely hematopoietic (9), and that mixed venous PO2 (PV̄O2, a reflection of tissue PO2) remains constant (10).

Keywords

Hemoglobin Concentration Oxygen Transport Dissociation Curve Oxygen Affinity FEBS Letter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Samuel Charache
    • 1
  1. 1.Johns Hopkins University School of MedicineBaltimoreUSA

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