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Effects of Coronary Occlusion on Myocardial Oxygen and Pulsatile Intramyocardial Pressure

  • T. Koyama
  • T. Sasajima
  • T. Yagi
  • N. Miki
  • Y. Kikuchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Abstract

When the coronary artery is occluded, both the myocardial tissue PO2 and local contractile force decrease. However, the time courses of the decrease in PO2 and contractile force seem to be different; the PO2 of the inner portion of the ventricular myocardium decreases to 50% of the initial level in 30 seconds according to Winbury et al (1971), while the contractile force decreases to 40% of the control value in 10 seconds as seen in the figure shown by Theroux et al (1974). Since the relation between these two variables has not been studied systematically, we decided to investigate this by simultaneous measurements of the time courses of PO2 in terms of O2-availability (O2 current through the platinum electrode) and pulsatile intramyocardial pressure (IMP) of the myocardium perfused by the left anterior branch of the coronary artery (LAD).

Keywords

Capillary Blood Blood Flow Velocity Platinum Electrode Myocardial Tissue Coronary Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Winbury, M.M., Howe, B.B. and Weiss, H.R. (1971) Pharmac. & Exp. Ther. 176, 186.Google Scholar
  2. Theroux, V., Franklin, D., Ross, J. and Kemper, W.S. (1974) Circ. Res. 35, 896.PubMedGoogle Scholar
  3. Koyama, T., Yagi, T. and Kakiuchi, Y. (1976) Experientia 32, 1617.PubMedCrossRefGoogle Scholar
  4. Bruley, D.F. and Knisely, M.H. (1970) Chem. Eng. Progress, Symp. Series 66, 22.Google Scholar
  5. Mochizuki, M. This symposium.Google Scholar
  6. Thews, G. (1962) Pflűgers Arch. 276, 166.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • T. Koyama
    • 1
  • T. Sasajima
    • 1
  • T. Yagi
    • 1
  • N. Miki
    • 1
  • Y. Kikuchi
    • 1
  1. 1.Res. Inst. Appl. Electr.Hokkaido University060 SapporoJapan

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