Computer Simulation of the Human Thoracic Aorta to Evaluate the Possible Role of Smoking in Atherogenesis
An impaired oxygen delivery to arterial wall tissue has been implicated as one factor in the atherogenic process (Getz et al., 1969). The arterial wall has a precarious O2 supply because its luminal side is completely avascular. Thus, the only supply of O2 to the avascular tissue zone is by diffusion over rather long distances from two sources: (1) the arterial blood flowing within the lumen and (2) the blood flowing within the vasa vasorum, the microcirculation of the outer portion of the wall.
KeywordsArterial Wall Intimal Thickening Hypoxic Damage COHb Level Atherogenic Process
Unable to display preview. Download preview PDF.
- Goldstick, T.K., Schneiderman, G., and Mockros, L.F. (1977) Fed. Proc, 36, 513.Google Scholar
- Roughton, F.J.W., and Darling, R.C. (1944) Am. J. Physiol., 141, 17.Google Scholar
- Schneiderman, G. (1975) Ph.D. Thesis, Northwestern Univ., Evanston.Google Scholar
- Schneiderman, G., Goldstick, T.K., and Mockros, L.F. (1974a) Paper 13d, 67th Ann. Meeting, AIChE, Washington, D.C.Google Scholar
- Schneiderman, G., Goldstick, T.K., and Zuckerman, L. (1974b) Proc. 27th ACEMB, 16, 283.Google Scholar
- Schneiderman, G., Olson, E.A., Ellis, C.G., and Goldstick, T.K. (1977) Fed. Proc., 36, 513.Google Scholar